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Professor John A. Gatehouse

Emeritus Professor

M.A., D.Phil. (Oxon.)


Affiliations
AffiliationRoom numberTelephone
Emeritus Professor in the Department of Biosciences +44 (0) 191 33 41264

Biography

University of Durham (Department of Botany; Department of Biological Sciences; School of Biological and Biomedical Sciences):
Postdoctoral Research Assistant 1976-1979;
Addison Wheeler Research Fellow 1979-1984;
Lecturer 1984-1997;
Reader 1997-2011;

Professor 2011-present.

Currently Deputy Head of School and Director of Undergraduate Teaching

Scientific interests:
Two main areas of research are currently being pursued; Plant-Insect Interactions, and Recombinant Proteins.

Plant-Insect Interactions, and developing insect-resistant crops, form a multi-disciplinary research programme carried out in collaboration with the group of Prof. Angharad Gatehouse IRES, University of Newcastle, with Dr. Elaine Fitches at CSL York, and with other collaborators, both national and international. The programme has involved the study of both plant and insect biochemistry and molecular biology, to characterise the interaction between plants and their predators at the molecular level. Much current research involves the design and production of recombinant fusion proteins as novel insecticides. These proteins are based on plant lectins as carriers for a variety of toxins, including components from venoms of spiders, scorpions and parasitoid wasps. The research group has also been involved in the production and bioassay of insect-resistant transgenic plants, and in evaluating the effects of these plants on non-target organisms. We believe that genetically modified (GM) crops will make a valuable contribution to future agriculture, and, despite the negative image that has been falsely attributed to them, will come to be seen as an environmentally benign form of pest control.

The research group has extensive experience in the production of recombinant proteins in functional form, using various expression systems, but specialising in the yeast Pichia pastoris as an expression host. These proteins have been used as as starting points for mutagenesis programmes designed to produce novel proteins, for use as catalysts, and in pharmaceutical applications. 

Research interests

  • biochemistry and molecular biology of plant-insect interactions
  • genetic engineering of plants for insect resistance
  • expression of recombinant plant and insect proteins in microorganisms
  • protein engineering
  • plant biochemistry and molecular biology
  • insect biochemistry and molecular biology

Research groups

  • Durham Centre for Crop Improvement Technology
  • Molecular Plant Sciences

Esteem Indicators

  • 2006: Invited Speaker: Invited speaker for symposium on “Insect Parasitoids: from basic research to applications”, as part of International Congress of Insect Biotechnology and Industry, Korea, Aug. 2007

Publications

Chapter in book

Journal Article

  • Powell, M.E., Bradish, H.M., Cao, M., Makinson, R., Brown, A.P., Gatehouse, J.A. & Fitches, E.C. (2020). Demonstrating the potential of a novel spider venom based biopesticide for target-specific control of the small hive beetle, a serious pest of the European honey bee. Journal of Pest Science 93(1): 391-402.
  • Poll, A.A., Lee, J., Sanderson, R.A., Byrne, E., Gatehouse, J.A., Sadanandom, A., Gatehouse, A.M.R. & Edwards, M.G. (2020). Septoria Leaf Blotch and Reduced Nitrogen Availability Alter WRKY Transcription Factor Expression in a Codependent Manner. International Journal of Molecular Sciences 21(11): 4165.
  • Martínez-Alarcón, Dania, Varrot, Annabelle, Fitches, Elaine, Gatehouse, John A., Cao, Min, Pyati, Prashant, Blanco-Labra, Alejandro & Garcia-Gasca, Teresa (2020). Recombinant Lectin from Tepary Bean (Phaseolus acutifolius) with Specific Recognition for Cancer-Associated Glycans: Production, Structural Characterization, and Target Identification. Biomolecules 10(4): 654.
  • Cao, Min, Gatehouse, John & Fitches, Elaine (2018). A Systematic Study of RNAi Effects and dsRNA Stability in Tribolium castaneum and Acyrthosiphon pisum, Following Injection and Ingestion of Analogous dsRNAs. International Journal of Molecular Sciences 19(4): 1079.
  • Powell, Michelle, Pyati, Prashant, Cao, Min, Bell, Howard, Gatehouse, John A. & Fitches, Elaine (2017). Insecticidal effects of dsRNA targeting the Diap1 gene in dipteran pests. Scientific Reports 7(1): 15147.
  • Powell, M.E., Bradish, H.M., Gatehouse, J.A. & Fitches, E.C. (2017). Systemic RNAi in the small hive beetle (Aethina tumida Murray, Coleoptera: Nitidulidae), a serious pest of the European honey bee (Apis mellifera). Pest Management Science 73(1): 53-63.
  • Nakasu, Erich YT, Karamaouna, Filitsa, Partsinevelos, Georgios K, Abd El Halim, Hesham M, Fitches, Elaine C, Pyati, Prashant, Gatehouse, John A, Gatehouse, Angharad MR & Edwards, Martin G (2016). Sublethal effects of the insecticidal fusion protein ω-ACTX-Hv1a/GNA on the parasitoidEulophus pennicornisvia its hostLacanobia oleracea. Pest Management Science 72(3): 585-590.
  • Yang, S., Fitches, E., Pyati, P. & Gatehouse, J.A. (2015). Effect of insecticidal fusion proteins containing spider toxins targeting sodium and calcium ion channels on pyrethroid-resistant strains of peach-potato aphid (Myzus persicae). Pest Management Science 71(7): 951-956.
  • Guan, W., Ferry, N., Edwards, M.G., Bell, H.A., Othman, H., Gatehouse, J.A. & Gatehouse, A.M.R. (2015). Proteomic analysis shows that stress response proteins are significantly up-regulated in resistant diploid wheat (Triticum monococcum) in response to attack by the grain aphid (Sitobion avenae). Molecular Breeding 35(2): 57.
  • Price, D.R.G. & Gatehouse, J.A. (2014). Genome-wide annotation and functional identification of aphid GLUT-like sugar transporters. BMC Genomics 15: 647.
  • Nakasu, Y.E.T., Williamson, S.M., Edwards, M.G., Fitches, E.C., Gatehouse, J.A., Wright, G. & Gatehouse, A.M.R. (2014). Novel biopesticide based on a spider venom peptide shows no adverse effects on honeybees. Proceedings of the Royal Society B: Biological Sciences 281(1787): 20140619.
  • Nakasu, Erich Y.T., Edwards, Martin G., Fitches, Elaine C., Gatehouse, John A. & Gatehouse, Angharad M.R. (2014). Transgenic plants expressing -ACTX-Hv1a and snowdrop lectin (GNA) fusion protein show enhanced resistance to aphids. Frontiers in Plant Science 5: 673.
  • Yang, S., Pyati, P., Fitches, E. & Gatehouse, J.A. (2014). A recombinant fusion protein containing a spider toxin specific for the insect voltage-gated sodium ion channel shows oral toxicity towards insects of different orders. Insect Biochemistry and Molecular Biology 47: 1-11.
  • Pyati, P., Fitches, E. & Gatehouse, J.A. (2014). Optimising expression of the recombinant fusion protein biopesticide ω-hexatoxin-Hv1a /GNA in Pichia pastoris: Sequence modifications and a simple method for the generation of multi-copy strains. Journal of Industrial Microbiology & Biotechnology 41(8): 1237-1247.
  • Fitches, E.C., Pyati, P., King, G.F. & Gatehouse, J.A. (2012). Fusion to snowdrop lectin magnifies the oral activity of insecticidal omega-Hexatoxin-Hv1a peptide by enabling its delivery to the central nervous system. PLoS ONE 7(6): e39389.
  • Pyati, Prashant, Chellamuthu, Anitha, Gatehouse, Angharad M. R., Fitches, Elaine & Gatehouse, John A. (2012). Insecticidal activity of wheat Hessian fly responsive proteins HFR-1 and HFR-3 towards a non-target wheat pest, cereal aphid (Sitobion avenae F.). Journal of Insect Physiology 58(7): 991-999.
  • Gatehouse, J.A. (2011). Prospects for using proteinase inhibitors to protect transgenic plants against attack by herbivorous insects. Current protein and peptide science 12(5): 409-416.
  • Bruce, C., Fitches, E.C., Chougule, N., Bell, H.A. & Gatehouse, J.A. (2011). Recombinant conotoxin, TxVIA, produced in yeast has insecticidal activity. Toxicon 58(1): 93-100.
  • Fang, Q, Wang, F, Gatehouse, J.A., Gatehouse, A.M.R., Chen, X-X, Hu, C & Ye, G-Y (2011). Venom of Parasitoid, Pteromalus puparum, Suppresses Host, Pieris rapae, Immune Promotion by Decreasing Host C-Type Lectin Gene Expression. PLoS ONE 6(10): e26888.
  • Ferry, N., Stavroulakis, S., Guan, W., Davison, G.M., Bell, H.A., Weaver, R.J., Down, R.E., Gatehouse, J.A. & Gatehouse, A.M.R. (2011). Molecular interactions between wheat and cereal aphid (Sitobion avenae): Analysis of changes to the wheat proteome. PROTEOMICS 11(10): 1985-2002.
  • Pyati, P., Bandani, A.R., Fitches, E. & Gatehouse, J.A. (2011). Protein digestion in cereal aphids (Sitobion avenae) as a target for plant defence by endogenous proteinase inhibitors. Journal of Insect Physiology 57(7): 881-891.
  • Vasconcelos, E.A., Santana, C.G.,, Godoy, C.V., Seixas, C.D., Silva, M.S., Moreira, L.R.S., Oliviera-Neto, O.B., Price, D., Fitches, E., Filho, E.D.F., Mehta, A., Gatehouse, J.A. & Grossi-de-Sa, M.F. (2011). A new chitinase-like xylanase inhibitor protein (XIP) from coffee (Coffea arabica) affects Soybean Asian rust (Phakopsora pachyrhizi) spore germination. BMC Biotechnology 11: 14.
  • The International Aphid Genomics Consortium. (2010). Genome Sequence of the Pea Aphid Acyrthosiphon pisum. PLoS Biology 8(2): e1000313.
  • Edwards, MG, Gatehouse, JA & Gatehouse AMR (2010). Molecular and biochemical characterisation of a dual proteolytic system in vine weevil larvae (Otiorhynchus sulcatus Coleoptera: Curculionidae). Insect Biochemistry and Molecular Biology 40(11): 785-791.
  • Fitches, EC, Bell, HA, Powell, ME, Back, E, Sargiotti, C, Weaver, RJ & Gatehouse, JA (2010). Insecticidal activity of scorpion toxin (ButaIT) and snowdrop lectin (GNA) containing fusion proteins towards pest species of different orders. Pest Management Science 66(1): 74-83.
  • Price, DRG, Tibbles, K, Shigenobu, S, Smertenko, A, Russell, CW, Douglas, AE, Fitches, E, Gatehouse, AMR & Gatehouse, JA (2010). Sugar transporters of the major facilitator superfamily in aphids; from gene prediction to functional characterization. Insect Molecular Biology 19(S2): 97-112.
  • Hinchliffe, G, Bown, DP, Gatehouse, JA & Fitches, E (2010). Insecticidal activity of recombinant avidin produced in yeast. Journal of Insect Physiology 56(6): 629-639.
  • Price, DRG, Bell, HA, Hinchliffe, G, Fitches, E, Weaver, R, & Gatehouse, JA (2009). A venom metalloproteinase from the parasitic wasp Eulophus pennicornis is toxic towards its host, tomato moth (Lacanobia oleracae). Insect Molecular Biology 18(2): 195-202.
  • Pyati, PS, Bell, HA, Fitches, E, Price, DRG, Gatehouse, AMR & Gatehouse, JA (2009). Cathepsin L-like cysteine proteinase (DcCathL) from Delia coarctata (wheat bulb fly): Basis of insecticidal activity. Insect Biochemistry and Molecular Biology 39(8): 535-546.
  • Chougule, N, Doyle, E, Fitches, E & Gatehouse, JA (2008). Biochemical characterization of midgut digestive proteases from Mamestra brassicae (cabbage moth; Lepidoptera Noctuidae) and effect of soybean Kunitz inhibitor (SKTI) in feeding assays. Journal of Insect Physiology 54(3): 563-572.
  • Fitches, E, Philip, J, Hinchliffe, G, Vercruysse, L, Chougule, N & Gatehouse, JA (2008). An evaluation of garlic lectin as an alternative carrier domain for insecticidal fusion proteins. Insect Science 15(6): 483-495.
  • Fitches, E, Wiles, D, Douglas, AE, Hinchliffe, G, Audsley, N & Gatehouse, JA (2008). The insecticidal activity of recombinant garlic lectins towards aphids. Insect Biochemistry and Molecular Biology 38(10): 905-915.
  • Gatehouse, JA (2008). Biotechnological prospects for engineering insect-resistant plants. Plant Physiology 146(3): 881-887.
  • Price, DRG & Gatehouse, JA (2008). RNAi-mediated crop protection against insects. Trends in Biotechnology 26(7): 393-400.
  • Li, H, Tang, H, Sivakumar, S, Philip, J, Harrison, RL, Gatehouse, JA & Bonning, BC (2008). Insecticidal activity of a basement membrane-degrading protease against Heliothis virescens (Fabricius) and Acyrthosiphon pisum (Harris). Journal of Insect Physiology 54(5): 777-789.
  • Price, DRG, Wilkinson, HS & Gatehouse, JA (2007). Functional expression and characterisation of a gut facilitative glucose transporter, NIHT1, from the phloem-feeding insect Nilaparvata lugens (rice brown planthopper. Insect Biochemistry and Molecular Biology 37(11): 1138-1148.
  • van Lith, M., Karala, A., Bown, D., Gatehouse, J., Ruddock, L., Saunders, P & Benham, AM. (2007). A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells. Molecular Biology of the Cell 18(8): 2795-2804.
  • Price, D.R.G., Karley, A.J., Ashford, D.A., Isaacs, H.V., Pownall, M.E., Wilkinson, H.S., Gatehouse, J.A. & Douglas, A.E. (2007). Molecular characterisation of a candidate gut sucrase in the pea aphid, Acyrthosiphon pisum. Insect biochemistry and molecular biology 37(4): 307-317.
  • Philip, J.M.D., Fitches, E., Harrison, R.L., Bonning, B. & Gatehouse, J.A. (2007). Characterisation of functional and insecticidal properties of a recombinant cathepsin L-like proteinase from flesh fly (Sarcophaga peregrina), which plays a role in differentiation of imaginal discs. Insect biochemistry and molecular biology 37(6): 589-600.
  • Ferry, N, Edwards, M, Gatehouse, J, Capell, T, Christou, P & Gatehouse, A (2006). Transgenic plants for insect pest control: A forward looking scientificperspective. Transgenic Research 15(1): 13-19.
  • Niittylä, T., Comparot-Moss, S., Lue, W.-L., Messerli, G., Trevisan, M., Seymour, M.D.J., Gatehouse, J.A., Villadsen, D., Smith, S.M., Chen, J., Zeeman, S.C. & Smith, A.M. (2006). Similar Protein Phosphatases Control Starch Metabolism in Plants and Glycogen Metabolism in Mammals. Journal of Biological Chemistry 281(17): 11815-11818.
  • Trung, NP, Fitches, E & Gatehouse, JA (2006). A fusion protein containing a lepidopteran-specific toxin from the South Indian red scorpion (Mesobuthus tamulus) and snowdrop lectin shows oral toxicity to target insects. BMC Biotechnology 6: 18.
  • Down, RE, Fitches, EC, Wiles, DP, Corti, P, Bell, HA, Gatehouse, JA & Edwards, JP (2006). Insecticidal spider venom toxin fused to snowdrop lectin is toxic to the peach-potato aphid, Myzus persicae (Hemiptera Aphididae) and the rice brown planthopper, Nilaparvata lugens (Hemiptera Delphacidae). Pest Management Science 62(1): 77-85.
  • Van Lith, M., Bown, D., Gatehouse, J. & Benham, A. M. (2006). Localisation and expression of a testis-specific protein disulfide isomerase, PDILT. Faseb Journal 20(4): A500-A501.
  • Hancock, SM, Corbett, K, Fordham-Skelton, AP, Gatehouse, JA & Davis, BG (2005). Developing promiscuous glycosidases for glycoside synthesis: ResiduesW433 and E432 in Sulfolobus solfataricus beta-glycosidase are importantglucoside- and galactoside-specificity determinants. Chembiochem 6(5): 866-875.
  • Srinivasan, A, Chougule, NP, Giri, AP, Gatehouse, JA & Gupta, VS (2005). Podborer (Helicoverpa armigera Hubn.) does not show specificadaptations in gut proteinases to dietary Cicer arietinum Kunitzproteinase inhibitor. Journal Of Insect Physiology 51(11): 1268-1276.
  • Bell, HA, Down, RE, Edwards, JP, Gatehouse, JA & Gatehouse, AMR (2005). Digestive proteolytic activity in the gut and salivary glands of thepredatory bug Podisus maculiventris (Heteroptera Pentatomidae);effect of proteinase inhibitors. European Journal Of Entomology 102(2): 139-145.
  • Ferry, N, Jouanin, L, Ceci, LR, Mulligan, A, Emami, K, Gatehouse, JA & Gatehouse, AMR (2005). Impact of oilseed rape expressing the insecticidal serine proteaseinhibitor, mustard trypsin inhibitor-2 on the beneficial predatorPterostichus madidus. Molecular Ecology 14(1): 337-349.
  • Mehlo, L, Gahakwa, D, Nghia, PT, Loc, NT, Capell, T, Gatehouse, JA, Gatehouse, AMR & Christou, P (2005). An alternative strategy for sustainable pest resistance in genetically enhanced crops. Proceedings Of The National Academy Of Sciences Of The United States Of America 102(22): 7812-7816.
  • Srinivasan, A, Giri, AP, Harsulkar, AM, Gatehouse, JA & Gupta, VS (2005). A Kunitz trypsin inhibitor from chickpea (Cicer arietinum L.) that exerts anti-metabolic effect on podborer (Helicoverpa armigera) larvae. Plant Molecular Biology 57(3): 359-374.
  • Bown, DP & Gatehouse, JA (2004). Characterization of a digestive carboxypeptidase from the insect pest corn earworm (Helicoverpa armigera) with novel specificity towards C-terminal glutamate residues. European Journal Of Biochemistry 271(10): 2000-2011.
  • Ferry, N, Edwards, MG, Gatehouse, JA & Gatehouse, AMR (2004). Plant-insect interactions: molecular approaches to insect resistance. Current Opinion In Biotechnology 15(2): 155-161.
  • Fitches, E, Edwards, MG, Mee, C, Grishin, E, Gatehouse, AMR, Edwards, JP & Gatehouse, JA (2004). Fusion proteins containing insect-specific toxins as pest control agents: snowdrop lectin delivers fused insecticidal spider venom toxinto insect haemolymph following oral ingestion. Journal Of Insect Physiology 50(1): 61-71.
  • Fitches, E, Wilkinson, H, Bell, H, Bown, DP, Gatehouse, JA & Edwards, JP (2004). Cloning, expression and functional characterisation of chitinase from larvae of tomato moth (Lacanobia oleracea): a demonstration of the insecticidal activity of insect chitinase. Insect Biochemistry And Molecular Biology 34(10): 1037-1050.
  • Bown, DP, Wilkinson, HS, Jongsma, MA & Gatehouse, JA (2004). Characterisation of cysteine proteinases responsible for digestive proteolysis in guts of larval western corn rootworm (Diabrotica virgifera) by expression in the yeast Pichia pastoris. Insect Biochemistry And Molecular Biology 34(4): 305-320.
  • Bown, DP, Wilkinson, HS & Gatehouse, JA (2004). Regulation of expression of genes encoding digestive proteases in thegut of a polyphagous lepidopteran larva in response to dietary proteaseinhibitors. Physiological Entomology 29(3): 278-290.
  • Price, DRG, Du, J, Dinsmore, A & Gatehouse, JA (2004). Molecular cloning and immunolocalization of a diuretic hormone receptor in rice brown planthopper (Nilaparvata lugens). Insect Molecular Biology 13(5): 469-480.
  • Ferry, N, Raemaekers, RJM, Majerus, MEN, Jouanin, L, Port, G, Gatehouse, JA & Gatehouse, AMR (2003). Impact of oilseed rape expressing the insecticidal cysteine proteaseinhibitor oryzacystatin on the beneficial predator Harmonia axyridis(multicoloured Asian ladybeetle). Molecular Ecology 12(2): 493-504.
  • Down, RE, Ford, L, Woodhouse, SD, Davison, GM, Majerus, MEN, Gatehouse, JA & Gatehouse, AMR (2003). Tritrophic interactions between transgenic potato expressing snowdroplectin (GNA), an aphid pest (peach-potato aphid; Myzus persicae (Sulz.)and a beneficial predator (2-spot ladybird; Adalia bipunctata L.). Transgenic Research 12(2): 229-241.
  • Nagadhara, D, Ramesh, S, Pasalu, IC, Rao, YK, Krishnaiah, NV, Sarma, NP, Bown, DP, Gatehouse, JA, Reddy, VD & Rao, KV (2003). Transgenic indica rice resistant to sap-sucking insects. Plant Biotechnology Journal 1(3): 231-240.
  • Loc, NT, Tinjuangjun, P, Gatehouse, AMR, Christou, P & Gatehouse, JA (2002). Linear transgene constructs lacking vector backbone sequences generatetransgenic rice plants which accumulate higher levels of proteinsconferring insect resistance. Molecular Breeding 9(4): 231-244.
  • Fordham-Skelton, AP, Chilley, P, Lumbreras, V, Reignoux, S, Fenton, TR, Dahm, CC, Pages, M & Gatehouse, JA (2002). A novel higher plant protein tyrosine phosphatase interacts with SNF1-related protein kinases via a KIS (kinase interaction sequence) domain. Plant Journal 29(6): 705-715.
  • Gatehouse, JA (2002). Plant resistance towards insect herbivores: a dynamic interaction. New Phytologist 156(2): 145-169.
  • Fitches, E, Audsley, N, Gatehouse, JA & Edwards, JP (2002). Fusion proteins containing neuropeptides as novel insect control agents: snowdrop lectin delivers fused allatostatin to insect haemolymph following oral ingestion. Insect Biochemistry And Molecular Biology 32(12): 1653-1661.
  • Foissac, X, Edwards, MG, Du, JP, Gatehouse, AMR & Gatehouse, JA (2002). Putative protein digestion in a sap-sucking homopteran plant pest (rice brown plant hopper; Nilaparvata lugens: Delphacidae) - identification of trypsin-like and cathepsin B-like proteases. Insect Biochemistry And Molecular Biology 32(9): 967-978.
  • Maqbool, SB, Riazuddin, S, Loc, NT, Gatehouse, AMR, Gatehouse, JA & Christou, P (2001). Expression of multiple insecticidal genes confers broad resistanceagainst a range of different rice pests. Molecular Breeding 7(1): 85-93.
  • Fitches, E, Ilett, C, Gatehouse, AMR, Gatehouse, LN, Greene, R, Edwards, JP & Gatehouse, JA (2001). The effects of Phaseolus vulgaris erythro- and leucoagglutinatingisolectins (PHA-E and PHA-L) delivered via artificial diet andtransgenic plants on the growth and development of tomato moth(Lacanobia oleracea) larvae; lectin binding to gut glycoproteins i. Journal Of Insect Physiology 47(12): 1389-1398.
  • Bell, HA, Fitches, EC, Marris, GC, Bell, J, Edwards, JP, Gatehouse, JA & Gatehouse, AMR (2001). Transgenic GNA expressing potato plants augment the beneficialbiocontrol of Lacanobia oleracea (Lepidoptera; Noctuidae) by theparasitoid Eulophus pennicornis (Hymenoptera; eulophidae). Transgenic Research 10(1): 35-42.
  • Down, RE, Ford, L, Bedford, SJ, Gatehouse, LN, Newell, C, Gatehouse, JA & Gatehouse, AMR (2001). Influence of plant development and environment on transgene expressionin potato and consequences for insect resistance. Transgenic Research 10(3): 223-236.
  • Bell, HA, Fitches, EC, Down, RE, Ford, L, Marris, GC, Edwards, JP, Gatehouse, JA & Gatehouse, AMR (2001). Effect of dietary cowpea trypsin inhibitor (CpTI) on the growth anddevelopment of the tomato moth Lacanobia oleracea (LepidopteraNoctuidae) and on the success of the gregarious ectoparasitoid Eulophuspennicornis (Hymenoptera Eulophidae). Pest Management Science 57(1): 57-65.
  • Estebanez-Perpina, E, Bayes, A, Vendrell, J, Jongsma, MA, Bown, DP, Gatehouse, JA, Huber, R, Bode, W, Aviles, FX & Reverter, D (2001). Crystal structure of a novel mid-gut procarboxypeptidase from thecotton pest Helicoverpa armigera. Journal Of Molecular Biology 313(3): 629-638.
  • Fitches, E, Woodhouse, SD, Edwards, JP & Gatehouse, JA (2001). In vitro and in vivo binding of snowdrop (Galanthus nivalis agglutinin;GNA) and jackbean (Canavalia ensiformis; Con A) lectins within tomatomoth (Lacanobia oleracea) larvae; mechanisms of insecticidal action. Journal Of Insect Physiology 47(7): 777-787.
  • Corbett, K, Fordham-Skelton, AP, Gatehouse, JA & Davis, BG (2001). Tailoring the substrate specificity of the beta-glycosidase from thethermophilic archaeon Sulfolobus solfataricus. Febs Letters 509(3): 355-360.
  • Du, JP, Foissac, X, Carss, A, Gatehouse, AMR & Gatehouse, JA (2000). Ferritin acts as the most abundant binding protein for snowdrop lectinin the midgut of rice brown planthoppers (Nilaparvata lugens). Insect Biochemistry And Molecular Biology 30(4): 297-305.
  • Tinjuangjun, P, Loc, NT, Gatehouse, AMR, Gatehouse, JA & Christou, P (2000). Enhanced insect resistance in Thai rice varieties generated by particlebombardment. Molecular Breeding 6(4): 391-399.
  • Down, RE, Ford, L, Woodhouse, SD, Raemaekers, RJM, Leitch, B, Gatehouse, JA & Gatehouse, AMR (2000). Snowdrop lectin (GNA) has no acute toxic effects on a beneficial insectpredator, the 2-spot ladybird (Adalia bipunctata L.). Journal Of Insect Physiology 46(4): 379-391.
  • Gatehouse, J (2000). Pusztai's misconceptions. Chemistry & Industry (10): 332-332.
  • Foissac, X, Loc, NT, Christou, P, Gatehouse, AMR & Gatehouse, JA (2000). Resistance to green leafhopper (Nephotettix virescens) and brown planthopper (Nilaparvata lugens) in transgenic rice expressing snowdrop lectin (Galanthus nivalis agglutinin; GNA). Journal Of Insect Physiology 46(4): 573-583.
  • Birch, ANE, Geoghegan, IE, Majerus, MEN, McNicol, JW, Hackett, CA, Gatehouse, AMR & Gatehouse, JA (1999). Tri-trophic interactions involving pest aphids, predatory 2-spotladybirds and transgenic potatoes expressing snowdrop lectin for aphidresistance. Molecular Breeding 5(1): 75-83.
  • Gatehouse, AMR, Davison, GM, Stewart, JN, Galehouse, LN, Kumar, A, Geoghegan, IE, Birch, ANE & Gatehouse, JA (1999). Concanavalin A inhibits development of tomato moth (Lacanobia oleracea)and peach-potato aphid (Myzus persicae) when expressed in transgenicpotato plants. Molecular Breeding 5(2): 153-165.
  • Bell, HA, Fitches, EC, Down, RE, Marris, GC, Edwards, JP, Gatehouse, JA & Gatehouse, AMR (1999). The effect of snowdrop lectin (GNA) delivered via artificial diet andtransgenic plants on Eulophus pennicornis (Hymenoptera Eulophidae), aparasitoid of the tomato moth Lacanobia oleracea (LepidopteraNoctuidae). Journal Of Insect Physiology 45(11): 983-991.
  • Tang, KX, Tinjuangjun, P, Xu, Y, Sun, XF, Gatehouse, JA, Ronald, PC, Qi, HX, Lu, XG, Christou, P & Kohli, A (1999). Particle-bombardment-mediated co-transformation of elite Chinese ricecultivars with genes conferring resistance to bacterial blight andsap-sucking insect pests. Planta 208(4): 552-563.
  • Down, RE, Ford, L, Mosson, HJ, Fitches, E, Gatehouse, JA & Gatehouse, AMR (1999). Protease activity in the larval stage of the parasitoid wasp, Eulophuspennicornis (Nees) (Hymenoptera Eulophidae); effects of proteaseinhibitors. Parasitology 119: 157-166.
  • Webb, KJ, Humphreys, MO, Skot, L, Gibbs, M & Gatehouse, J (1999). Inheritance and expression of transgenes in T-2 and T-3 generations ofLotus corniculatus transformed using Agrobacterium tumefaciens. Euphytica 108(3): 169-179.
  • Raemaekers, RJM, de Muro, L, Gatehouse, JA & Fordham-Skelton, AP (1999). Functional phytohemagglutinin (PHA) and Galanthus nivalis agglutinin (GNA) expressed in Pichia pastoris - Correct N-terminal processing and secretion of heterologous proteins expressed using the PHA-E signal peptide. European Journal Of Biochemistry 265(1): 394-403.
  • Gatehouse, AMR, Norton, E, Davison, GM, Babbe, SM, Newell, CA & Gatehouse, JA (1999). Digestive proteolytic activity in larvae of tomato moth, Lacanobiaoleracea; effects of plant protease inhibitors in vitro and in vivo. Journal Of Insect Physiology 45(6): 545-558.
  • Stoger, E, Williams, S, Christou, P, Down, RE & Gatehouse, JA (1999). Expression of the insecticidal lectin from snowdrop (Galanthus nivalisagglutinin; GNA) in transgenic wheat plants: effects on predation bythe grain aphid Sitobion avenae. Molecular Breeding 5(1): 65-73.
  • Fordham-Skelton, AP, Skipsey, M, Eveans, IM, Edwards, R & Gatehouse, JA (1999). Higher plant tyrosine-specific protein phosphatases (PTPs) containnovel amino-terminal domains: expression during embryogenesis. Plant Molecular Biology 39(3): 593-605.
  • Longstaff, M, Powell, KS, Gatehouse, JA, Raemaekers, R, Nevell, CA & Hamilton, WDO (1998). Production and purification of active snowdrop lectin in Escherichiacoli. European Journal Of Biochemistry 252(1): 59-65.
  • Gatehouse, AMR & Gatehouse, JA (1998). Identifying proteins with insecticidal activity: Use of encoding genesto produce insect-resistant transgenic crops. Pesticide Science 52(2): 165-175.
  • Rao, KV, Rathore, KS, Hodges, TK, Fu, X, Stoger, E, Sudhakar, D, Williams, S, Christou, P, Bharathi, M, Bown, DP, Powell, KS, Spence, J, Gatehouse, AMR & Gatehouse, JA (1998). Expression of snowdrop lectin (GNA) in transgenic rice plants confers resistance to rice brown planthopper. Plant Journal 15(4): 469-477.
  • Bown, DP, Wilkinson, HS & Gatehouse, JA (1998). Midgut carboxypeptidase from Helicoverpa armigera (LepidopteraNoctuidae) larvae: enzyme characterisation, cDNA cloning and expression. Insect Biochemistry And Molecular Biology 28(10): 739-749.
  • Powell, KS, Spence, J, Bharathi, M, Gatehouse, JA & Gatehouse, AMR (1998). Immunohistochemical and developmental studies to elucidate the mechanism of action of the snowdrop lectin on the rice brown planthopper, Nilaparvata lugens (Stal). Journal Of Insect Physiology 44(7-8): 529-539.
  • Walker, AJ, Ford, L, Majerus, MEN, Geoghegan, IE, Birch, N, Gatehouse, JA & Gatehouse, AMR (1998). Characterisation of the mid-gut digestive proteinase activity of thetwo-spot ladybird (Adalia bipunctata L.) and its sensitivity toproteinase inhibitors. Insect Biochemistry And Molecular Biology 28(3): 173-180.
  • Sudhakar, D, Fu, XD, Stoger, E, Williams, S, Spence, J, Brown, DP, Bharath, M, Gatehouse, JA & Christou, P (1998). Expression and immunolocalisation of the snowdrop lectin, GNA intransgenic rice plants. Transgenic Research 7(5): 371-378.
  • Fitches, E & Gatehouse, JA (1998). A comparison of the short and long term effects of insecticidal lectinson the activities of soluble and brush border enzymes of tomato mothlarvae (Lacanobia oleracea). Journal Of Insect Physiology 44(12): 1213-1224.
  • Dhankher, OP, Drew, JE & Gatehouse, JA (1997). Characterisation of a pea hsp70 gene which is both developmentally andstress-regulated. Plant Molecular Biology 34(2): 345-352.
  • Bown, DP, Wilkinson, HS & Gatehouse, JA (1997). Differentially regulated inhibitor-sensitive and insensitive protease genes from the phytophagous insect pest, Helicoverpa armigera, are members of complex multigene families. Insect Biochemistry And Molecular Biology 27(7): 625-638.
  • Fitches, E, Gatehouse, AMR & Gatehouse, JA (1997). Effects of snowdrop lectin (GNA) delivered via artificial diet andtransgenic plants on the development of tomato moth (Lacanobiaoleracea) larvae in laboratory and glasshouse trials. Journal Of Insect Physiology 43(8): 727-739.
  • Gatehouse, AMR, Davison, GM, Newell, CA, Merryweather, A, Hamilton, WDO, Burgess, EPJ, Gilbert, RJC & Gatehouse, JA (1997). Transgenic potato plants with enhanced resistance to the tomato moth,Lacanobia oleracea: Growth room trials. Molecular Breeding 3(1): 49-63.
  • Howley, PM & Gatehouse, JA (1997). A 38 bp repeat sequence within the pea seed storage protein promoter of legA is a binding site for a nuclear DNA-binding protein. Plant Molecular Biology 33(1): 175-180.
  • Down, RE, Gatehouse, AMR, Hamilton, WDO & Gatehouse, JA (1996). Snowdrop lectin inhibits development and decreases fecundity of theglasshouse potato aphid (Aulacorthum solani) when administered in vitroand via transgenic plants both in laboratory and glasshouse trials. Journal Of Insect Physiology 42(11-12): 1035-1045.
  • Webb, KJ, Gibbs, MJ, Mizen, S, Skot, L & Gatehouse, JA (1996). Genetic transformation of Lotus corniculatus with Agrobacteriumtumefaciens and the analysis of the inheritance of transgenes in theT-1 generation. Transgenic Research 5(5): 303-312.
  • Gatehouse, AMR, Down, RE, Powell, KS, Sauvion, N, Rahbe, Y, Newell, CA, Merryweather, A, Hamilton, WDO & Gatehouse, JA (1996). Transgenic potato plants with enhanced resistance to the peach-potatoaphid Myzus persicae. Entomologia Experimentalis Et Applicata 79(3): 295-307.
  • Edmonds, HS, Gatehouse, LN, Hilder, VA & Gatehouse, JA (1996). The inhibitory effects of the cysteine protease inhibitor,oryzacystatin, on digestive proteases and on larval survival anddevelopment of the southern corn rootworm (Diabrotica undecimpunctatahowardi). Entomologia Experimentalis Et Applicata 78(1): 83-94.
  • Sauvion, N, Rahbe, Y, Peumans, WJ, VanDamme, EJM, Gatehouse, JA & Gatehouse, AMR (1996). Effects of GNA and other mannose binding lectins on development andfecundity of the peach-potato aphid Myzus persicae. Entomologia Experimentalis Et Applicata 79(3): 285-293.
  • POWELL, KS, GATEHOUSE, AMR, HILDER, VA, VANDAMME, EJM, PEUMANS, WJ, BOONJAWAT, J, HORSHAM, K & GATEHOUSE, JA (1995). DIFFERENT ANTIMETABOLIC EFFECTS OF RELATED LECTINS TOWARDS NYMPHALSTAGES OF NILAPARVATA-LUGENS. Entomologia Experimentalis Et Applicata 75(1): 61-65.
  • POWELL, KS, GATEHOUSE, AMR, HILDER, VA & GATEHOUSE, JA (1995). ANTIFEEDANT EFFECTS OF PLANT-LECTINS AND AN ENZYME ON THE ADULT STAGEOF THE RICE BROWN PLANTHOPPER, NILAPARVATA-LUGENS. Entomologia Experimentalis Et Applicata 75(1): 51-59.
  • HAIDER, A, BADR, A, GATEHOUSE, J, HAMOUD, M, SAMMOUR, R & BOULTER, D (1995). EXPRESSION OF UBIQUITIN DURING LATE EMBRYOGENESIS IN PEA (PISUM-SATIVUML). Plant Physiology 108(2): 153-153.
  • HILDER, VA, POWELL, KS, GATEHOUSE, AMR, GATEHOUSE, JA, GATEHOUSE, LN, SHI, Y, HAMILTON, WDO, MERRYWEATHER, A, NEWELL, CA, TIMANS, JC, PEUMANS, WJ, VANDAMME, E & BOULTER, D (1995). EXPRESSION OF SNOWDROP LECTIN IN TRANSGENIC TOBACCO PLANTS RESULTS INADDED PROTECTION AGAINST APHIDS. Transgenic Research 4(1): 18-25.
  • JOHNSTON, KA, LEE, MJ, BROUGH, G, HILDER, VA, GATEHOUSE, AMR & GATEHOUSE, JA (1995). PROTEASE ACTIVITIES IN THE LARVAL MIDGUT OF HELIOTHIS-VIRESCENS -EVIDENCE FOR TRYPSIN AND CHYMOTRYPSIN-LIKE ENZYMES. Insect Biochemistry And Molecular Biology 25(3): 375-383.
  • SHI, Y, WANG, MB, POWELL, KS, VANDAMME, E, HILDER, VA, GATEHOUSE, AMR, BOULTER, D & GATEHOUSE, JA (1994). USE OF THE RICE SUCROSE SYNTHASE-1 PROMOTER TO DIRECT PHLOEM-SPECIFICEXPRESSION OF BETA-GLUCURONIDASE AND SNOWDROP LECTIN GENES INTRANSGENIC TOBACCO PLANTS. Journal Of Experimental Botany 45(274): 623-631.
  • WANG, MB, BOULTER, D & GATEHOUSE, JA (1994). CHARACTERIZATION AND SEQUENCING OF CDNA CLONE ENCODING THE PHLOEMPROTEIN PP2 OF CUCURBITA-PEPO. Plant Molecular Biology 24(1): 159-170.
  • GATEHOUSE, JA, GATEHOUSE, AMR, POWELL, KS, SHI, Y, WANG, MB, BROUGH, C, HILDER, VA & BOULTER, D (1994). NOVEL GENES FOR THE PRODUCTION OF INSECT-RESISTANT TRANSGENIC PLANTS. Journal Of Cellular Biochemistry 75-75.
  • GATEHOUSE, AMR, HILDER, VA, POWELL, KS, WANG, M, DAVISON, GM, GATEHOUSE, LN, DOWN, RE, EDMONDS, HS, BOULTER, D, NEWELL, CA, MERRYWEATHER, A, HAMILTON, WDO & GATEHOUSE, JA (1994). INSECT-RESISTANT TRANSGENIC PLANTS - CHOOSING THE GENE TO DO THE JOB. Biochemical Society Transactions 22(4): 944-949.
  • DREW, JE & GATEHOUSE, JA (1994). ISOLATION AND CHARACTERIZATION OF A PEA POD CDNA-ENCODING A PUTATIVEBLUE COPPER PROTEIN CORRELATED WITH LIGNIN DEPOSITION. Journal Of Experimental Botany 45(281): 1873-1884.
  • DREW, JE, BOWN, D & GATEHOUSE, JA (1993). SEQUENCE OF A NOVEL PLANT RAS-RELATED CDNA FROM PISUM-SATIVUM. Plant Molecular Biology 21(6): 1195-1199.
  • JOHNSTON, KA, GATEHOUSE, JA & ANSTEE, JH (1993). EFFECTS OF SOYBEAN PROTEASE INHIBITORS ON THE GROWTH AND DEVELOPMENT OFLARVAL HELICOVERPA-ARMIGERA. Journal Of Insect Physiology 39(8): 657-664.
  • BOWN, DP, BOLWELL, GP & GATEHOUSE, JA (1993). CHARACTERIZATION OF POTATO (SOLANUM-TUBEROSUM L.) EXTENSINS - A NOVELEXTENSIN-LIKE CDNA FROM DORMANT TUBERS. Gene 134(2): 229-233.
  • GATEHOUSE, AMR, SHI, Y, POWELL, KS, BROUGH, C, HILDER, VA, HAMILTON, WDO, NEWELL, CA, MERRYWEATHER, A, BOULTER, D & GATEHOUSE, JA (1993). APPROACHES TO INSECT RESISTANCE USING TRANSGENIC PLANTS. Philosophical Transactions Of The Royal Society Of London Series B-biological Sciences 342(1301): 279-286.
  • POWELL, KS, GATEHOUSE, AMR, HILDER, VA & GATEHOUSE, JA (1993). ANTIMETABOLIC EFFECTS OF PLANT-LECTINS AND PLANT AND FUNGAL ENZYMES ONTHE NYMPHAL STAGES OF 2 IMPORTANT RICE PESTS, NILAPARVATA-LUGENS ANDNEPHOTETTIX-CINCITEPS. Entomologia Experimentalis Et Applicata 66(2): 119-126.
  • WANG, MB, BOULTER, D & GATEHOUSE, JA (1992). A COMPLETE SEQUENCE OF THE RICE SUCROSE SYNTHASE-1 (RSS1) GENE. Plant Molecular Biology 19(5): 881-885.
  • GATEHOUSE, AMR, HILDER, VA & GATEHOUSE, JA (1992). CONTROL OF INSECT PESTS BY PLANT GENETIC-ENGINEERING. Proceedings Of The Royal Society Of Edinburgh Section B-biological Sciences 99: 51-60.
  • EVANS, KM, GATEHOUSE, JA, LINDSAY, WP, SHI, J, TOMMEY, AM & ROBINSON, NJ (1992). EXPRESSION OF THE PEA METALLOTHIONEIN-LIKE GENE PSMTA INESCHERICHIA-COLI AND ARABIDOPSIS-THALIANA AND ANALYSIS OF TRACE-METALION ACCUMULATION - IMPLICATIONS FOR PSMTA FUNCTION. Plant Molecular Biology 20(6): 1019-1028.
  • THOMPSON, AJ, BOWN, D, YAISH, S & GATEHOUSE, JA (1991). DIFFERENTIAL EXPRESSION OF SEED STORAGE PROTEIN GENES IN THE PEA-LEGJSUBFAMILY - SEQUENCE OF GENE-LEGK. Biochemie Und Physiologie Der Pflanzen 187(1): 1-12.
  • GATEHOUSE, AMR, HOWE, DS, FLEMMING, JE, HILDER, VA & GATEHOUSE, JA (1991). BIOCHEMICAL BASIS OF INSECT RESISTANCE IN WINGED BEAN(PSOPHOCARPUS-TETRAGONOLOBUS) SEEDS. Journal Of The Science Of Food And Agriculture 55(1): 63-74.
  • JOHNSTON, KA, LEE, MJ, GATEHOUSE, JA & ANSTEE, JH (1991). THE PARTIAL-PURIFICATION AND CHARACTERIZATION OF SERINE PROTEASEACTIVITY IN MIDGUT OF LARVAL HELICOVERPA-ARMIGERA. Insect Biochemistry 21(4): 389-397.
  • MEAKIN, PJ & GATEHOUSE, JA (1991). INTERACTION OF SEED NUCLEAR PROTEINS WITH TRANSCRIPTIONALLY-ENHANCINGREGIONS OF THE PEA (PISUM-SATIVUM L) LEGA GENE PROMOTER. Planta 183(4): 471-477.
  • DALE, AS, ELVIN, P, YARWOOD, JN & GATEHOUSE, JA (1991). INTRODUCTION OF SULFHYDRYL-GROUPS INTO PEA VICILIN - FORMATION OFINTRA-POLYPEPTIDE AND INTER-POLYPEPTIDE DISULFIDE BONDS. Journal Of The Science Of Food And Agriculture 55(4): 551-562.
  • SHIRSAT, AH, MEAKIN, PJ & GATEHOUSE, JA (1990). SEQUENCES 5' TO THE CONSERVED 28 BP LEG BOX ELEMENT REGULATE THEEXPRESSION OF PEA SEED STORAGE PROTEIN GENE LEGA. Plant Molecular Biology 15(5): 685-693.
  • EVANS, IM, GATEHOUSE, LN, GATEHOUSE, JA, ROBINSON, NJ & CROY, RRD (1990). A GENE FROM PEA (PISUM-SATIVUM L) WITH HOMOLOGY TO METALLOTHIONEIN GENES. Febs Letters 262(1): 29-32.
  • MINNEY, BHP, GATEHOUSE, AMR, DOBIE, P, DENDY, J, CARDONA, C & GATEHOUSE, JA (1990). BIOCHEMICAL-BASES OF SEED RESISTANCE TO ZABROTES-SUBFASCIATUS (BEANWEEVIL) IN PHASEOLUS-VULGARIS (COMMON BEAN) - A MECHANISM FOR ARCELINTOXICITY. Journal Of Insect Physiology 36(10): 757-&.
  • GATEHOUSE, LN, EVANS, IM, GATEHOUSE, JA & CROY, RRD (1990). CHARACTERIZATION OF A RAPE (BRASSICA-NAPUS L) EXTENSIN GENE ENCODING APOLYPEPTIDE RELATIVELY RICH IN TYROSINE. Plant Science 71(2): 223-231.
  • SCUTT, CP, GATES, PJ, GATEHOUSE, JA, BOULTER, D & CROY, RRD (1990). A CDNA-ENCODING AN S-LOCUS SPECIFIC GLYCOPROTEIN FROM BRASSICA-OLERACEAPLANTS CONTAINING THE S5 SELF-INCOMPATIBILITY ALLELE. Molecular & General Genetics 220(3): 409-413.
  • BOULTER, D, EDWARDS, GA, GATEHOUSE, AMR, GATEHOUSE, JA & HILDER, VA (1990). ADDITIVE PROTECTIVE EFFECTS OF DIFFERENT PLANT-DERIVED INSECTRESISTANCE GENES IN TRANSGENIC TOBACCO PLANTS. Crop Protection 9(5): 351-354.
  • EVANS, IM, GATEHOUSE, LN, GATEHOUSE, JA, YARWOOD, JN, BOULTER, D & CROY, RRD (1990). THE EXTENSIN GENE FAMILY IN OILSEED RAPE (BRASSICA-NAPUS L) -CHARACTERIZATION OF SEQUENCES OF REPRESENTATIVE MEMBERS OF THE FAMILY. Molecular & General Genetics 223(2): 273-287.
  • BOULTER, D, GATEHOUSE, JA, GATEHOUSE, AMR & HILDER, VA (1990). GENETIC-ENGINEERING OF PLANTS FOR INSECT RESISTANCE. Endeavour 14(4): 185-190.
  • THOMPSON, AJ, EVANS, IM, BOULTER, D, CROY, RRD & GATEHOUSE, JA (1989). TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF SEEDSTORAGE-PROTEIN GENE-EXPRESSION IN PEA (PISUM-SATIVUM-L). Planta 179(3): 279-287.
  • RAO, R, COSTA, A, CROY, RRD, BOULTER, D & GATEHOUSE, JA (1989). VARIATION IN POLYPEPTIDES OF THE MAJOR ALBUMIN PROTEIN OF PEA(PISUM-SATIVUM-L) - INHERITANCE AND MOLECULAR ANALYSIS. Molecular & General Genetics 219(1-2): 277-281.
  • HILDER, VA, BARKER, RF, SAMOUR, RA, GATEHOUSE, AMR, GATEHOUSE, JA & BOULTER, D (1989). PROTEIN AND CDNA SEQUENCES OF BOWMAN-BIRK PROTEASE INHIBITORS FROM THECOWPEA (VIGNA-UNGUICULATA WALP). Plant Molecular Biology 13(6): 701-710.
  • ELLIS, JR, SHIRSAT, AH, HEPHER, A, YARWOOD, JN, GATEHOUSE, JA, CROY, RRD & BOULTER, D (1988). TISSUE-SPECIFIC EXPRESSION OF A PEA LEGUMIN GENE IN SEEDS OFNICOTIANA-PLUMBAGINIFOLIA. Plant Molecular Biology 10(3): 203-214.
  • EVANS, IM, SWINHOE, R, GATEHOUSE, LN, GATEHOUSE, JA & BOULTER, D (1988). DISTRIBUTION OF ROOT MESSENGER-RNA SPECIES IN OTHER VEGETATIVE ORGANSOF PEA (PISUM-SATIVUM-L). Molecular & General Genetics 214(1): 153-157.
  • GATEHOUSE, JA, BOWN, D, GILROY, J, LEVASSEUR, M, CASTLETON, J & ELLIS, THN (1988). 2 GENES ENCODING MINOR LEGUMIN POLYPEPTIDES IN PEA (PISUM-SATIVUM-L) -CHARACTERIZATION AND COMPLETE SEQUENCE OF THE LEGJ GENE. Biochemical Journal 250(1): 15-24.
  • CROY, RRD, EVANS, IM, YARWOOD, JN, HARRIS, N, GATEHOUSE, JA, SHIRSAT, AH, KANG, A, ELLIS, JR, THOMPSON, A & BOULTER, D (1988). EXPRESSION OF PEA LEGUMIN SEQUENCES IN PEA, NICOTIANA AND YEAST. Biochemie Und Physiologie Der Pflanzen 183(2-3): 183-197.
  • BOWN, D, ELLIS, THN & GATEHOUSE, JA (1988). THE SEQUENCE OF A GENE ENCODING CONVICILIN FROM PEA (PISUM-SATIVUM-L)SHOWS THAT CONVICILIN DIFFERS FROM VICILIN BY AN INSERTION NEAR THEN-TERMINUS. Biochemical Journal 251(3): 717-726.
  • WATSON, MD, LAMBERT, N, DELAUNEY, A, YARWOOD, JN, CROY, RRD, GATEHOUSE, JA, WRIGHT, DJ & BOULTER, D (1988). ISOLATION AND EXPRESSION OF A PEA VICILIN CDNA IN THE YEASTSACCHAROMYCES-CEREVISIAE. Biochemical Journal 251(3): 857-864.
  • GATEHOUSE, JA, BOWN, D, EVANS, IM, GATEHOUSE, LN, JOBES, D, PRESTON, P & CROY, RRD (1987). SEQUENCE OF THE SEED LECTIN GENE FROM PEA (PISUM-SATIVUM-L). Nucleic Acids Research 15(18): 7642-7642.
  • DURANTI, M, GATEHOUSE, JA, BOULTER, D & CERLETTI, P (1987). INVITRO PROTEOLYTIC PROCESSING OF PEA AND JACK BEAN STORAGE PROTEINS BYAN ENDOPEPTIDASE FROM LUPIN SEEDS. Phytochemistry 26(3): 627-631.
  • SAWYER, RM, BOULTER, D & GATEHOUSE, JA (1987). NUCLEASE SENSITIVITY OF STORAGE-PROTEIN GENES IN ISOLATED-NUCLEI OFPEA-SEEDS. Planta 171(2): 254-258.
  • BOULTER, D, EVANS, IM, ELLIS, JR, SHIRSAT, A, GATEHOUSE, JA & CROY, RRD (1987). DIFFERENTIAL GENE-EXPRESSION IN THE DEVELOPMENT OF PISUM-SATIVUM. Plant Physiology And Biochemistry 25(3): 283-289.
  • YARWOOD, JN, HARRIS, N, DELAUNEY, A, CROY, RRD, GATEHOUSE, JA, WATSON, MD & BOULTER, D (1987). CONSTRUCTION OF A HYBRID CDNA-ENCODING A MAJOR LEGUMIN PRECURSORPOLYPEPTIDE AND ITS EXPRESSION AND LOCALIZATION INSACCHAROMYCES-CEREVISIAE. Febs Letters 222(1): 175-180.
  • GATEHOUSE, JA, EVANS, IM, CROY, RRD & BOULTER, D (1986). DIFFERENTIAL EXPRESSION OF GENES DURING LEGUME SEED DEVELOPMENT. Philosophical Transactions Of The Royal Society Of London Series B-biological Sciences 314(1166): 367-384.
  • WATERHOUSE, RN, BOULTER, D & GATEHOUSE, JA (1986). AN ORGAN-SPECIFIC HYPOMETHYLATION OF COTYLEDON GENOMIC RDNA INPISUM-SATIVUM-L. Febs Letters 209(2): 223-226.
  • EVANS, IM, GATEHOUSE, JA & BOULTER, D (1985). REGULATION OF STORAGE-PROTEIN SYNTHESIS IN PEA (PISUM-SATIVUM-L)COTYLEDONS UNDER CONDITIONS OF SULFUR DEFICIENCY. Biochemical Journal 232(1): 261-265.
  • GATEHOUSE, JA & BOULTER, D (1985). PLANT BIOCHEMISTRY - SEED PROTEIN CONSTRUCTION. Nature 313(5997): 13-13.
  • BOWN, D, LEVASSEUR, M, CROY, RRD, BOULTER, D & GATEHOUSE, JA (1985). SEQUENCE OF A PSEUDOGENE IN THE LEGUMIN GENE FAMILY OF PEA(PISUM-SATIVUM-L). Nucleic Acids Research 13(12): 4527-4538.
  • EVANS, IM, BOWN, D, LYCETT, GW, CROY, RRD, BOULTER, D & GATEHOUSE, JA (1985). TRANSCRIPTION OF A LEGUMIN GENE FROM PEA (PISUM-SATIVUM-L) INVITRO. Planta 165(4): 554-560.
  • MAPLESTONE, P, ALLISON, J, HUSSEIN, EHA, ELDIN, AEYG, GATEHOUSE, JA & BOULTER, D (1985). VARIATION OF THE LEGUMIN SEED STORAGE PROTEIN AMONGST VICIA SPECIES. Phytochemistry 24(8): 1717-1723.
  • CROY, RRD, LYCETT, GW, GATEHOUSE, JA, EVANS, M, SHIRSAT, A, LEVASSEUR, M & BOULTER, D (1985). THE LEGUMIN GENE FAMILY OF PEA. Journal Of The Science Of Food And Agriculture 36(8): 658-658.
  • GATEHOUSE, JA, GILROY, J, HOQUE, MS & CROY, RRD (1985). PURIFICATION, PROPERTIES AND AMINO-ACID SEQUENCE OF A LOW-MR ABUNDANTSEED PROTEIN FROM PEA (PISUM-SATIVUM-L). Biochemical Journal 225(1): 239-247.
  • GATEHOUSE, AMR, BUTLER, KJ, FENTON, KA & GATEHOUSE, JA (1985). PRESENCE AND PARTIAL CHARACTERIZATION OF A MAJOR PROTEOLYTIC-ENZYME INTHE LARVAL GUT OF CALLOSOBRUCHUS-MACULATUS. Entomologia Experimentalis Et Applicata 39(3): 279-286.
  • CROY, RRD, HOQUE, MS, GATEHOUSE, JA & BOULTER, D (1984). THE MAJOR ALBUMIN PROTEINS FROM PEA (PISUM-SATIVUM-L) - PURIFICATIONAND SOME PROPERTIES. Biochemical Journal 218(3): 795-803.
  • MAHMOUD, SH, GATEHOUSE, JA & BOULTER, D (1984). INHERITANCE AND MAPPING OF ISOENZYMES IN PEA (PISUM-SATIVUM-L). Theoretical And Applied Genetics 68(6): 559-566.
  • SAMMOUR, RH, GATEHOUSE, JA, GILROY, J & BOULTER, D (1984). THE HOMOLOGY OF THE MAJOR STORAGE PROTEIN OF JACK BEAN(CANAVALIA-ENSIFORMIS) TO PEA VICILIN AND ITS SEPARATION FROMALPHA-MANNOSIDASE. Planta 161(1): 61-70.
  • GATEHOUSE, JA, CROY, RRD & BOULTER, D (1984). THE SYNTHESIS AND STRUCTURE OF PEA STORAGE PROTEINS. Crc Critical Reviews In Plant Sciences 1(4): 287-314.
  • MAHMOUD, SH & GATEHOUSE, JA (1984). INHERITANCE AND MAPPING OF VICILIN STORAGE PROTEIN GENES INPISUM-SATIVUM-L. Heredity 53(AUG): 185-&.
  • EVANS, IM, GATEHOUSE, JA, CROY, RRD & BOULTER, D (1984). REGULATION OF THE TRANSCRIPTION OF STORAGE-PROTEIN MESSENGER-RNA INNUCLEI ISOLATED FROM DEVELOPING PEA (PISUM-SATIVUM-L) COTYLEDONS. Planta 160(6): 559-568.
  • EVANS, IM, GATEHOUSE, JA, LYCETT, GW & BOULTER, D (1984). USE OF SYNTHETIC OLIGODEOXYRIBONUCLEOTIDES AND PRIMED CDNA AS PROBESFOR PEA (PISUM-SATIVUM-L) RNA AND GENOMIC DNA-SEQUENCES. Plant Molecular Biology 3(2): 73-81.
  • GATEHOUSE, JA, CROY, RRD, EVANS, IM, LYCETT, GW & BOULTER, D (1984). PEA SEED STORAGE PROTEINS AND THEIR ENCODING GENES. Heredity 53(DEC): 573-573.
  • LYCETT, GW, DELAUNEY, AJ, ZHAO, W, GATEHOUSE, JA, CROY, RRD & BOULTER, D (1984). 2 CDNA CLONES CODING FOR THE LEGUMIN PROTEIN OF PISUM-SATIVUM-L CONTAINSEQUENCE REPEATS. Plant Molecular Biology 3(2): 91-96.
  • MORTON, H, EVANS, IM, GATEHOUSE, JA & BOULTER, D (1983). SEQUENCE COMPLEXITY OF MESSENGER-RNA IN COTYLEDONS OF DEVELOPING PEA(PISUM-SATIVUM) SEEDS. Phytochemistry 22(4): 807-812.
  • LYCETT, GW, DELAUNEY, AJ, GATEHOUSE, JA, GILROY, J, CROY, RRD & BOULTER, D (1983). THE VICILIN GENE FAMILY OF PEA (PISUM-SATIVUM-L) - A COMPLETE CDNACODING SEQUENCE FOR PREPROVICILIN. Nucleic Acids Research 11(8): 2367-2380.
  • LYCETT, GW, CROY, RRD, GATEHOUSE, JA, DELAUNEY, AJ & BOULTER, D (1983). SEQUENCING OF CDNAS FROM PEA. Heredity 51(OCT): 522-522.
  • ZHAO, WM, GATEHOUSE, JA & BOULTER, D (1983). THE PURIFICATION AND PARTIAL AMINO-ACID-SEQUENCE OF A POLYPEPTIDE FROMTHE GLUTELIN FRACTION OF RICE GRAINS - HOMOLOGY TO PEA LEGUMIN. Febs Letters 162(1): 96-102.
  • GATEHOUSE, JA, LYCETT, GW, DELAUNEY, AJ, CROY, RRD & BOULTER, D (1983). SEQUENCE SPECIFICITY OF THE POST-TRANSLATIONAL PROTEOLYTIC CLEAVAGE OFVICILIN, A SEED STORAGE PROTEIN OF PEA (PISUM-SATIVUM-L). Biochemical Journal 212(2): 427-432.
  • MORTON, H, EVANS, IM, GATEHOUSE, JA & BOULTER, D (1983). CELL-FREE TRANSLATION SYSTEMS FROM NEW SOURCES - PEA COTYLEDONS ANDRICE GERM. Phytochemistry 22(1): 25-26.
  • GATEHOUSE, JA, LYCETT, GW, CROY, RRD & BOULTER, D (1982). THE POST-TRANSLATIONAL PROTEOLYSIS OF THE SUBUNITS OF VICILIN FROM PEA(PISUM-SATIVUM-L). Biochemical Journal 207(3): 629-632.
  • HIRANO, H, GATEHOUSE, JA & BOULTER, D (1982). THE COMPLETE AMINO-ACID-SEQUENCE OF A SUBUNIT OF THE VICILIN SEEDSTORAGE PROTEIN OF PEA (PISUM-SATIVUM-L). Febs Letters 145(1): 99-102.
  • GATEHOUSE, JA, EVANS, IM, BOWN, D, CROY, RRD & BOULTER, D (1982). CONTROL OF STORAGE-PROTEIN SYNTHESIS DURING SEED DEVELOPMENT IN PEA(PISUM-SATIVUM-L). Biochemical Journal 208(1): 119-127.
  • CROY, RRD, LYCETT, GW, GATEHOUSE, JA, YARWOOD, JN & BOULTER, D (1982). CLONING AND ANALYSIS OF CDNAS ENCODING PLANT-STORAGE PROTEIN PRECURSORS. Nature 295(5844): 76-79.
  • MATTA, NK & GATEHOUSE, JA (1982). INHERITANCE AND MAPPING OF STORAGE PROTEIN GENES IN PISUM-SATIVUM-L. Heredity 48(JUN): 383-&.
  • GATEHOUSE, JA, CROY, RRD, MORTON, H, TYLER, M & BOULTER, D (1981). CHARACTERIZATION AND SUBUNIT STRUCTURES OF THE VICILIN STORAGE PROTEINSOF PEA (PISUM-SATIVUM-L). European Journal Of Biochemistry 118(3): 627-633.
  • MATTA, NK & GATEHOUSE, JA (1981). MODIFICATION OF THE BASIC SUBUNITS OF PEA LEGUMIN ON STORAGE. Phytochemistry 20(12): 2621-2623.
  • MATTA, N, GATEHOUSE, JA & BOULTER, D (1981). THE STRUCTURE OF LEGUMIN OF VICIA-FABA L - A REAPPRAISAL. Journal Of Experimental Botany 32(126): 183-197.
  • MATTA, NK, GATEHOUSE, JA & BOULTER, D (1981). MOLECULAR AND SUBUNIT HETEROGENEITY OF LEGUMIN OF PISUM-SATIVUM-L(GARDEN PEA) - A MULTIDIMENSIONAL GEL-ELECTROPHORETIC STUDY. Journal Of Experimental Botany 32(131): 1295-1307.
  • CROY, RRD, GATEHOUSE, JA, EVANS, IM & BOULTER, D (1980). CHARACTERIZATION OF THE STORAGE PROTEIN SUBUNITS SYNTHESIZED INVITRO BYPOLYRIBOSOMES AND RNA FROM DEVELOPING PEA (PISUM-SATIVUM-L)2. VICILIN. Planta 148(1): 57-63.
  • GATEHOUSE, JA, CROY, RRD & BOULTER, D (1980). ISOELECTRIC-FOCUSING PROPERTIES AND CARBOHYDRATE CONTENT OF PEA(PISUM-SATIVUM) LEGUMIN. Biochemical Journal 185(2): 497-503.
  • CROY, RRD, GATEHOUSE, JA, TYLER, M & BOULTER, D (1980). THE PURIFICATION AND CHARACTERIZATION OF A 3RD STORAGE PROTEIN(CONVICILIN) FROM THE SEEDS OF PEA (PISUM-SATIVUM-L). Biochemical Journal 191(2): 509-516.
  • GATEHOUSE, AMR, GATEHOUSE, JA & BOULTER, D (1980). ISOLATION AND CHARACTERIZATION OF TRYPSIN-INHIBITORS FROM COWPEA(VIGNA-UNGUICULATA). Phytochemistry 19(5): 751-756.
  • GATEHOUSE, JA & BOULTER, D (1980). ISOLATION AND PROPERTIES OF A LECTIN FROM THE ROOTS OF PISUM-SATIVUM(GARDEN PEA). Physiologia Plantarum 49(4): 437-442.
  • CROY, RRD, GATEHOUSE, JA, EVANS, IM & BOULTER, D (1980). CHARACTERIZATION OF THE STORAGE PROTEIN SUBUNITS SYNTHESIZED INVITRO BYPOLYRIBOSOMES AND RNA FROM DEVELOPING PEA (PISUM-SATIVUM-L)1. LEGUMIN. Planta 148(1): 49-56.
  • KHAN, RI, GATEHOUSE, JA & BOULTER, D (1980). THE SEED PROTEINS OF COWPEA (VIGNA-UNGUICULATA-L WALP). Journal Of Experimental Botany 31(125): 1599-1611.
  • GATEHOUSE, AMR, GATEHOUSE, JA, DOBIE, P, KILMINSTER, AM & BOULTER, D (1979). BIOCHEMICAL BASIS OF INSECT RESISTANCE IN VIGNA-UNGUICULATA. Journal Of The Science Of Food And Agriculture 30(10): 948-958.
  • BOULTER, D & GATEHOUSE, JA (1979). SOME BIOCHEMICAL ASPECTS OF THE EFFICIENCY OF PLANTS. Qualitas Plantarum-plant Foods For Human Nutrition 29(1-2): 187-195.
  • GATEHOUSE, JA & GATEHOUSE, AMR (1979). 2 SIMPLE QUANTITATIVE ASSAYS FOR TRYPSIN-INHIBITORS USING IMMOBILIZEDTRYPSIN. Analytical Biochemistry 98(2): 438-444.
  • GATEHOUSE, JA & KNOWLES, JR (1977). PHOSPHOGLYCERATE MUTASE FROM WHEAT-GERM - STUDIES WITH ISOTOPICALLYLABELED 3-PHOSPHO-D-GLYCERATES SHOWING THAT CATALYZED REACTION ISINTRAMOLECULAR. Biochemistry 16(14): 3045-3050.
  • LEADLAY, PF, BREATHNACH, R, GATEHOUSE, J, JOHNSON, PE & KNOWLES, JR (1977). PHOSPHOGLYCERATE MUTASE FROM WHEAT-GERM - ISOLATION, CRYSTALLIZATION,AND PROPERTIES - APPENDIX. Biochemistry 16(14): 3050-3053.

Supervision students