Dr Max Brown
Postdoctoral Research Associate
BSc Hons, PhD
|Postdoctoral Research Associate in the Department of Biosciences||137|
I am a PDRA in the Department of Biosciences. I have ten years of experience as an active researcher in cell biology, focusing on the secretory pathway and more recently mechanobiology, collaborating with engineers and computer scientists.
My current project, in collaboration with industry, combines state of the art imaging techniques with mechanical stretching of mammalian cells. As part of this project, I have used CAD to design and build a user-friendly, microscope-mountable stretching device. In addition to this work, I am investigating collagen trafficking and synthesis through the secretory pathway.
I have been involved in multiple outreach projects from the Durham Science Festival to Parkinson's UK Research Awareness meetings.
I also enjoying creating video and other media to highlight and broaden the audience of my research and work. Click here to see the 2-minute video abstract I created for one of my recent publications
And another video here, which I created for Parkinson's UK to raise awareness of research and the 'Dave the worm' sponsorship scheme:
- Endoplasmic reticulum stress
- Duffy, Laura, Henderson, John, Brown, Max, Pryzborski, Stefan, Fullard, Nicola, Summa, Lena, Distler, Jorg H. W., Stratton, Richard & O’Reilly, Steven (2021). Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis. Frontiers in Cell and Developmental Biology 9: 681061.
- Yaseen, Bodoor, Lopez, Henry, Taki, Zeinab, Zafar, Sara, Rosario, Henrique, Abdi, Bahja Ahmed, Vigneswaran, Shivanee, Xing, Fiona, Arumalla, Nikita, Black, Simon, Ahmad, Sara, Kumar, Kimti, Gul, Rabia, Scolamiero, Laura, Morris, Sian, Bowman, Alex, Stainer, Anna, Rice, Alexandra, Stock, Carmel, Renzoni, Elisabetta, Denton, Christopher P, Venturini, Cristina, Brown, Max, O’Reilly, Steven & Stratton, Richard (2020). Interleukin-31 promotes pathogenic mechanisms underlying skin and lung fibrosis in scleroderma. Rheumatology 59(9): 2625.
- Brown, Max, Dainty, Samantha, Strudwick, Natalie, Mihai, Adina D., Watson, Jamie N., Dendooven, Robina, Paton, Adrienne W., Paton, James C. & Schröder, Martin (2020). Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesised insulin receptors to the cell surface. Molecular Biology of the Cell 31(23): 2495-2629.
- Henderson, John, Brown, Max, Horsburgh, Steven, Duffy, Laura, Wilkinson, Sarah, Worrell, Julie, Stratton, Richard & O’Reilly, Steven (2018). Methyl cap binding protein 2: a key epigenetic protein in systemic sclerosis. Rheumatology 58(3): 527.
- Brown, Max & O’Reilly, Steven (2018). Innate immunity and Toll-like receptor signaling in the pathogenesis of scleroderma: advances and opportunities for therapy. Current Opinion in Rheumatology 30(6): 600.
- Brown, M. & O'Reilly, S. (2018). The immunopathogenesis of fibrosis in systemic sclerosis. Clinical & Experimental Immunology
- Armstrong, M. C., Sestak, S., Ali, A. A., Sagini, H. A. M., Brown, M., Baty, K., Treumann, A. & Schröder, M. (2017). Bypass of activation loop phosphorylation by aspartate 836 in activation of the endoribonuclease activity of Ire1. Molecular and Cellular Biology 37(16): e00655-16.
- Brown, M., Strudwick, N., Suwara, M., Sutcliffe, L. K., Mihai, A. D., Ali, A. A., Watson, J. N. & Schröder, M. (2016). An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response. Journal of Cell Science 129(12): 2317-2328.
- N. Strudwick, M. Brown, V. M. Parmar & M. Schröder (2010). Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on Nonfermentable Carbon Sources. Molecular and Cellular Biology 30(23): 5514-5530.