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2024

Michalczyk, E., Pakosz-Stepien, Z., Liston, J.D., Gittins, O., Pabis, M., Heddle, J.G., Ghilarov, D. Structural basis of chiral wrap and T-segment capture by Escherichia coli DNA gyrase. Proceedings of the National Academy of Sciences (2024) 121:e2407398121.

Acton, O.J., Sheppard, D., Kunzelmann, S., Caswell, S.J., Nans, A., Burgess, A.J. O., Kelly, G., Morris, E.R., Rosenthal, P.B., & Taylor, I.A. (2024). Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nature Communications (2024) 15:3775

Alpizar-Sosa, E.A., Zimbres, Z.M., Mantilla, B.S., Dickie, E.A, Wei, W., Burle-Caldas, G.A., Filipe, L.N.S, Van Bocxlaer, K., Price, H.P., Ibarra-Meneses, A.V., Beaudry, F., Fernandez-Prada, C., Whitfield, P.D., Barrett, M.P., Denny, P.W. Evaluation of the Leishmania inositol phosphorylceramide synthase as a drug target using a chemical and genetic approach. ACS Infectious Diseases (2024) 10:2913-2928

Azmi, N.N., Mahyudin, N.A., Omara, W.H.W., Abdullah, A.H., Ismail, R., Ishak, C.F., Sharples, G.J. Antibacterial mechanism of Malaysian Carey clay against food-borne Staphylococcus aureus. Natural Product Research (2024) 20:1-5

Leslie, K.G., Jolliffe, K.A., Müllner, M., New, E.J., Turnbull, W.B., Fascione, M.A., Friman, V.-P., Mahon, C.S A Glycopolymer sensor array that differentiates lectins and bacteria. Biomacromolecules (2024) 25:7466-7474

2023

Salivary Antimicrobial Peptide Histatin-5 Does Not Display Zn(II)-Dependent or -Independent Activity against Streptococci. Stewart LJ, Hong Y, Holmes IR, Firth SJ, Ahmed Y, Quinn J, Santos Y, Cobb SL, Jakubovics NS, Djoko KY. ACS Infect Dis. 2023; 10;9(3):631-642. doi: 10.1021/acsinfecdis.2c00578.

Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages. Porta EO, Gao L, Denny PW, Steel PG, Kalesh K. Microbiol Spectr. 2023; 31:e0296023. doi: 10.1128/spectrum.02960-23.

Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells. Tsai MC, Caswell SJ, Morris ER, Mann MC, Pennell S, Kelly G, Groom HCT, Taylor IA, Bishop KN. Retrovirology. 2023;20(1):5. doi: 10.1186/s12977-023-00620-z.

A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of Escherichia coli to metal restriction. Paterson JR, Wadsworth JM, Hu P, Sharples GJ. Microb Genom. 2023; 9(12). doi: 10.1099/mgen.0.001153.

Publications

2022

Paterson, J.R., Beecroft, M.S, Mulla, R.S., Osman, D., Reeder, N.L., Casserta, J.A., Young, T.R., Pettigrew, C.A., Davies, G.E., Williams, J.A.G., and Sharples, G.J. (2022) Insights into the antibacterial mechanism of action of chelating agents by selective deprivation of iron, manganese and zinc. Applied and Environmental Microbiology 88:e1641-21

2021

Mina, J.G.M., Charlton, R.L., Alpizar-Sosa E,., Escrivani D.O., Brown, C., Alqaisi, A., Borsodi, M.P.G., Figueiredo, C.P., de Lima, E.V., Dickie, E.A., Wei, W., Coutinho-Silva, R., Merritt, A., Smith, T.K., Barrett, M.P., Rossi-Bergmann, B., Denny, P.W.., Steel, P.G. (2021) Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase. ACS Infectious Diseases 7(1): 47-63.

Mantilla, B.S., Azevedo, C., Denny, P.W., Saiardi, and A. Docampo, R. (2021) The histidine ammonia lyase of Trypanosoma cruzi is involved in acidocalcisome alkalinization and is esssential for survival under starvation conditions. mBio 12(6):e0198121

Escrivani, D.O., Charlton, R.L., Brigido, M.C., Burle-Caldas, G.A., Borsodi, M.P.G., Zingali, R.B., Palmeira de Mello, M.V., Barbosa de Jesus, J., Teles de Souza, A.M., Abrahim-Vieira, B., Freitag-Pohl, S., Pohl, E., Denny, P.W., Rossi-Bergmann, B. and Steel, P.G. (2021) Chalcones Identify cTXNPx as a Potential Antileishmanial Drug Target. PLoS NTD 15(11):e0009951

Picton, D.M.Luyten, Y.A., Morgan, R.D.Nelson, A.Smith D.L.Dryden D.T.F.Hinton J.C.D. and Blower, T.R. (2021) The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses. Nucleic Acid Research 49(19):11257-11273

Morris, E.R., Kunzelmann, S., Caswell, S.J., Purkiss, A.G., Kelly, G., & Taylor, I.A. (2021) Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry 60(21):1682-1698 https://doi.org/10.1021/acs.biochem.0c00944

2020

Cai, Y., Usher, B., Gutierrez, C., Tolcan, A., Mansour, M., Fineran, P.C., Condon, C., Neyrolles, O., Genevaux, P. & Blower, T.R. (2020). A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stemsScience Advances 6(31): eabb6651.

Tusting, L.S., Bradley, J., Bhatt, S., Gibson, H.S., Weiss, D.J., Shenton, F.C., Lindsay, S.W. (2020). Environmental temperature and growth faltering in African children: a cross-sectional studyThe Lancet Planetary Health 4(3): e116.

Anderson, O., Beckett, J., Briggs, C.C., Natrass, L.A., Cranston, C.F., Wilkinson, E.J., Owen, J.H., Williams, R.M., Loukaidis, A., Bouillon, M.E., Pritchard, D., Lahmann, M., Baird, M.S. & Denny, P.W. (2020). An investigation of the antileishmanial properties of semi-synthetic saponinRSC Medicinal Chemistry 11(7): 833-842.

Stewart, L.J., Ong, C.Y., Zhang, M.M., Brouwer, S., McIntyre, L., Davies, M.R., Walker, M.J., McEwan, A.G., Waldron, K.J., Djoko, K.Y. Role of Glutathione in Buffering Excess Intracellular Copper in Streptococcus pyogenes. mBio. 2020 Dec 1;11(6):e02804-20

Morris, E.R., Caswell, S.J., Kunzelmann, S., Arnold, L.H., Purkiss, A.G., Kelly, G., & Taylor, I.A. (2020) Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun 11:3165 https://doi.org/10.1038/s41467-020-16983-2

  

2019

Tusting, L.S., Bisanzio, D., Alabaster, G., Cameron, E., Cibulskis, R., Davies, M., Flaxman, S., Gibson, H.S., Knudsen, J., Mbogo, C., Okumu, F.O., von Seidlein, L., Weiss, D.J., Lindsay, S.W., Gething, P.W. & Bhatt, S. (2019). Mapping changes in housing in sub-Saharan Africa from 2000 to 2015Nature 568: 391-394

Kalesh, K. & Denny, P.W. (2019). A BONCAT-iTRAQ method enables temporally resolved quantitative profiling of newly synthesised proteins in Leishmania mexicana parasites during starvationPLoS Neglected Tropical Diseases 13(2): e0007651.

Ritchie, A.W., Cox, H.J., Barrientos-Palomo, S.N., Sharples, G.J., Badyal, J.P.S. (2019). Bioinspired Multifunctional Polymer–Nanoparticle–Surfactant Complex Nanocomposite Surfaces for Antibacterial Oil–Water Separation. Colloids and Surfaces A: Physicochemical and Engineering Aspects 560: 352-359.

Melatti, C., Pieperhoff, M., Lemgruber, L., Pohl, E., Sheiner, L., Meissner, M. (2019). A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondiiPLoS Pathogens 15(4): e1007512.

Morris, E.R., & Taylor, I.A. (2019) The missing link: allostery and catalysis in the anti-viral protein SAMHD1. Biochem Soc Trans 47(4):1013–1027 https://doi.org/10.1042/BST20180348