Publications

2022

Paterson, J.R., Beecroft, M.S, Mulla, R.S., Osman, D., Reeder, N.L., Casserta, J.A., Young, T.R., Pettigrew, C.A., Davies, G.E., Williams, J.A.G., and Sharples, G.J. (2022) Insights into the antibacterial mechanism of action of chelating agents by selective deprivation of iron, manganese and zinc. Applied and Environmental Microbiology 88:e1641-21

2021

Mina, J.G.M., Charlton, R.L., Alpizar-Sosa E,., Escrivani D.O., Brown, C., Alqaisi, A., Borsodi, M.P.G., Figueiredo, C.P., de Lima, E.V., Dickie, E.A., Wei, W., Coutinho-Silva, R., Merritt, A., Smith, T.K., Barrett, M.P., Rossi-Bergmann, B., Denny, P.W.., Steel, P.G. (2021) Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase. ACS Infectious Diseases 7(1): 47-63.

Mantilla, B.S., Azevedo, C., Denny, P.W., Saiardi, and A. Docampo, R. (2021) The histidine ammonia lyase of Trypanosoma cruzi is involved in acidocalcisome alkalinization and is esssential for survival under starvation conditions. mBio 12(6):e0198121

Escrivani, D.O., Charlton, R.L., Brigido, M.C., Burle-Caldas, G.A., Borsodi, M.P.G., Zingali, R.B., Palmeira de Mello, M.V., Barbosa de Jesus, J., Teles de Souza, A.M., Abrahim-Vieira, B., Freitag-Pohl, S., Pohl, E., Denny, P.W., Rossi-Bergmann, B. and Steel, P.G. (2021) Chalcones Identify cTXNPx as a Potential Antileishmanial Drug Target. PLoS NTD 15(11):e0009951

Picton, D.M., Luyten, Y.A., Morgan, R.D., Nelson, A., Smith D.L., Dryden D.T.F., Hinton J.C.D. and Blower, T.R. (2021) The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses. Nucleic Acid Research 49(19):11257-11273

Morris, E.R., Kunzelmann, S., Caswell, S.J., Purkiss, A.G., Kelly, G., & Taylor, I.A. (2021) Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry 60(21):1682-1698 https://doi.org/10.1021/acs.biochem.0c00944

2020

Cai, Y., Usher, B., Gutierrez, C., Tolcan, A., Mansour, M., Fineran, P.C., Condon, C., Neyrolles, O., Genevaux, P. & Blower, T.R. (2020). A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems. Science Advances 6(31): eabb6651.

Tusting, L.S., Bradley, J., Bhatt, S., Gibson, H.S., Weiss, D.J., Shenton, F.C., Lindsay, S.W. (2020). Environmental temperature and growth faltering in African children: a cross-sectional study. The Lancet Planetary Health 4(3): e116.

Anderson, O., Beckett, J., Briggs, C.C., Natrass, L.A., Cranston, C.F., Wilkinson, E.J., Owen, J.H., Williams, R.M., Loukaidis, A., Bouillon, M.E., Pritchard, D., Lahmann, M., Baird, M.S. & Denny, P.W. (2020). An investigation of the antileishmanial properties of semi-synthetic saponin. RSC Medicinal Chemistry 11(7): 833-842.

Stewart, L.J., Ong, C.Y., Zhang, M.M., Brouwer, S., McIntyre, L., Davies, M.R., Walker, M.J., McEwan, A.G., Waldron, K.J., Djoko, K.Y. Role of Glutathione in Buffering Excess Intracellular Copper in Streptococcus pyogenes. mBio. 2020 Dec 1;11(6):e02804-20

Morris, E.R., Caswell, S.J., Kunzelmann, S., Arnold, L.H., Purkiss, A.G., Kelly, G., & Taylor, I.A. (2020) Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun 11:3165 https://doi.org/10.1038/s41467-020-16983-2

2019

Tusting, L.S., Bisanzio, D., Alabaster, G., Cameron, E., Cibulskis, R., Davies, M., Flaxman, S., Gibson, H.S., Knudsen, J., Mbogo, C., Okumu, F.O., von Seidlein, L., Weiss, D.J., Lindsay, S.W., Gething, P.W. & Bhatt, S. (2019). Mapping changes in housing in sub-Saharan Africa from 2000 to 2015. Nature 568: 391-394

Kalesh, K. & Denny, P.W. (2019). A BONCAT-iTRAQ method enables temporally resolved quantitative profiling of newly synthesised proteins in Leishmania mexicana parasites during starvation. PLoS Neglected Tropical Diseases 13(2): e0007651.

Ritchie, A.W., Cox, H.J., Barrientos-Palomo, S.N., Sharples, G.J., Badyal, J.P.S. (2019). Bioinspired Multifunctional Polymer–Nanoparticle–Surfactant Complex Nanocomposite Surfaces for Antibacterial Oil–Water Separation. Colloids and Surfaces A: Physicochemical and Engineering Aspects 560: 352-359.

Melatti, C., Pieperhoff, M., Lemgruber, L., Pohl, E., Sheiner, L., Meissner, M. (2019). A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii. PLoS Pathogens 15(4): e1007512.

Morris, E.R., & Taylor, I.A. (2019) The missing link: allostery and catalysis in the anti-viral protein SAMHD1. Biochem Soc Trans 47(4):1013–1027 https://doi.org/10.1042/BST20180348