Staff profile

I work on seaweed, primarily on their evolution and systematics, but also on their bioenergy potential and their ecological importance along the UK’s coastlines. 

My DPhil in Biochemistry was awarded in 2000 and between 2000-2007 I held postdoctoral research fellowships in Cambridge, Plymouth and Roscoff, taking a year off in 2002-2003 to play professional rugby. From 2009-2012, I held a Lectureship at Queen’s University Belfast and moved to Durham in 2013.

• The genetics, genomics and physiology of algal development
• Bioenergy generation and provision
• Seaweed systematics and evolution

Journal Article

• Pectin-like heteroxylans in the early-diverging charophyte Klebsormidium fluitans.
  
  Rapin, M. N., Bothwell, J. H., & Fry, S. C. (in press). Pectin-like heteroxylans in the early-diverging charophyte Klebsormidium fluitans. Annals of Botany, mcae154.
• Same but different — pseudo‐pectin in the charophytic alga Chlorokybus atmophyticus
  
  Rapin, M. N., Murray, L., Sadler, I. H., Bothwell, J. H., & Fry, S. C. (2023). Same but different — pseudo‐pectin in the charophytic alga Chlorokybus atmophyticus. Physiologia Plantarum, 175(6), Article e14079. https://doi.org/10.1111/ppl.14079
• Monitoring apoptosis in intact cells by high‐resolution magic angle spinning 1 H NMR spectroscopy
  
  Wylot, M., Whittaker, D. T., Wren, S. A., Bothwell, J. H., Hughes, L., & Griffin, J. L. (2021). Monitoring apoptosis in intact cells by high‐resolution magic angle spinning 1 H NMR spectroscopy. NMR in Biomedicine, 34(3), Article e4456. https://doi.org/10.1002/nbm.4456
• Insights into the Evolution of Multicellularity from the Sea Lettuce Genome
  
  De Clerck, O., Kao, S., Bogaert, K. A., Blomme, J., Foflonker, F., Kwantes, M., Vancaester, E., Vanderstraeten, L., Aydogdu, E., Boesger, J., Califano, G., Charrier, B., Clewes, R., Del Cortona, A., D’Hondt, S., Fernandez-Pozo, N., Gachon, C. M., Hanikenne, M., Lattermann, L., … Bothwell, J. H. (2018). Insights into the Evolution of Multicellularity from the Sea Lettuce Genome. Current Biology, 28(18), 2921-2933.e5. https://doi.org/10.1016/j.cub.2018.08.015
• Agrobacterium-mediated gene delivery and transient expression in the red macroalga Chondrus crispus
  
  Ramessur, A. D., Bothwell, J. H., Maggs, C. A., Gan, S. Y., & Phang, S. M. (2018). Agrobacterium-mediated gene delivery and transient expression in the red macroalga Chondrus crispus. Botanica Marina, 61(5), 499-510. https://doi.org/10.1515/bot-2018-0028
• The effects of spatial scale and isoscape on consumer isotopic niche width
  
  Reddin, C. J., Bothwell, J. H., O’Connor, N. E., & Harrod, C. (2018). The effects of spatial scale and isoscape on consumer isotopic niche width. Functional Ecology, 32(4), 904-915. https://doi.org/10.1111/1365-2435.13026
• An integrated process for the extraction of fuel and chemicals from marine macroalgal biomass
  
  Trivedi, N., Baghel, R. S., Bothwell, J., Gupta, V., Reddy, C., Lali, A. M., & Jha, B. (2016). An integrated process for the extraction of fuel and chemicals from marine macroalgal biomass. Scientific Reports, 6(1), Article 30728. https://doi.org/10.1038/srep30728
• Between-taxon matching of common and rare species richness patterns
  
  Reddin, C., Bothwell, J., & Lennon, J. (2015). Between-taxon matching of common and rare species richness patterns. Global Ecology and Biogeography, 24(12), 1476-1486. https://doi.org/10.1111/geb.12372
• Coastal Upwelling Drives Intertidal Assemblage Structure and Trophic Ecology
  
  Reddin, C., Docmac, F., O’Connor, N., Bothwell, J., & Harrod, C. (2015). Coastal Upwelling Drives Intertidal Assemblage Structure and Trophic Ecology. PLoS ONE, 10(7), Article e0130789. https://doi.org/10.1371/journal.pone.0130789
• The green seaweed Ulva: a model system to study morphogenesis
  
  Wichard, T., Charrier, B., Mineur, B., Bothwell, J., De Clerck, O., & Coates, J. (2015). The green seaweed Ulva: a model system to study morphogenesis. Frontiers in Plant Science, 6, Article 72. https://doi.org/10.3389/fpls.2015.00072
• A haploid system of sex determination in the brown alga Ectocarpus sp.
  
  Ahmed, S., Cock, J., Pessia, E., Luthringer, R., Cormier, A., Robuchon, M., Sterck, L., Peters, A., Dittami, S., Corre, E., Valero, M., Aury, J., Roze, D., Van de Peer, Y., Bothwell, J., Marais, G., & Coelho, S. (2014). A haploid system of sex determination in the brown alga Ectocarpus sp. Current Biology, 24(17), 1945-1957. https://doi.org/10.1016/j.cub.2014.07.042
• Genome structure and metabolic features in the red seaweed Chondrus crispus shed light on evolution in the Archaeplastida
  
  Collén, J., Porcel, B., Carré, W., Ball, S. G., Chaparro, C., Tonon, T., Barbeyron, T., Michel, G., Noel, B., Valentin, K., Elias, M., Artiguenave, F., Arun, A., Aury, J., Barbosa-Neto, J. F., Bothwell, J. H., Bouget, F., Brillet, L., Cabello-Hurtado, F., … Boyen, C. (2013). Genome structure and metabolic features in the red seaweed Chondrus crispus shed light on evolution in the Archaeplastida. Proceedings of the National Academy of Sciences, 110(13), 5247-5252. https://doi.org/10.1073/pnas.1221259110
• NOX or not? Evidence for algal NADPH oxidases
  
  Anderson, A., Bothwell, J. H., Laohavisit, A., Smith, A. G., & Davies, J. M. (2011). NOX or not? Evidence for algal NADPH oxidases. Trends in Plant Science, 16(11), 579-581. https://doi.org/10.1016/j.tplants.2011.09.003
• An introduction to biological nuclear magnetic resonance spectroscopy
  
  Bothwell, J. H., & Griffin, J. L. (2011). An introduction to biological nuclear magnetic resonance spectroscopy. Biological Reviews, 86(2), 493-510. https://doi.org/10.1111/j.1469-185x.2010.00157.x
• Role of endoreduplication and apomeiosis during parthenogenetic reproduction in the model brown alga Ectocarpus siliculosus.
  
  Bothwell, J., Marie, D., Peters, A., Cock, J., & Coelho, S. (2010). Role of endoreduplication and apomeiosis during parthenogenetic reproduction in the model brown alga Ectocarpus siliculosus. New Phytologist, 188(1), 111-121. https://doi.org/10.1111/j.1469-8137.2010.03357.x
• The Ectocarpus genome and the independent evolution of multicellularity in brown algae
  
  Cock, J. M., Sterck, L., Rouze, P., Scornet, D., Allen, A. E., Amoutzias, G., Anthouard, V., Artiguenave, F., Aury, J., Badger, J. H., Beszteri, B., Billiau, K., Bonnet, E., Bothwell, J. H., Bowler, C., Boyen, C., Brownlee, C., Carrano, C. J., Charrier, B., … Wincker, P. (2010). The Ectocarpus genome and the independent evolution of multicellularity in brown algae. Nature, 465(7298), 617-621. https://doi.org/10.1038/nature09016
• Ca2+ signals co-ordinate zygotic polarization and cell cycle progression in the brown alga, Fucus serratus.
  
  Bothwell, J., Kisielewska, J., Genner, M., McAinsh, M., & Brownlee, C. (2008). Ca2+ signals co-ordinate zygotic polarization and cell cycle progression in the brown alga, Fucus serratus. Development., 135(12), 2173-2181. https://doi.org/10.1242/dev.017558
• A tip-high, Ca2+-interdependent, reactive oxygen species gradient is associated with polarized growth in Fucus serratus zygotes.
  
  Coelho, S., Brownlee, C., & Bothwell, J. (2008). A tip-high, Ca2+-interdependent, reactiveoxygen species gradient is associated with polarized growth in Fucus serratus zygotes. Planta, 227(5), 1037-1046. https://doi.org/10.1007/s00425-007-0678-9
• Two voltage-dependent calcium channels co-exist in the apical plasma membrane of Arabidopsis thaliana root hairs.
  
  Miedema, H., Demidchik, V., Véry, A., Bothwell, J., Brownlee, C., & Davies, J. (2008). Two voltage-dependent calcium channels co-exist in the apical plasma membrane of Arabidopsis thalianaroot hairs. New Phytologist, 179(2). https://doi.org/10.1111/j.1469-8137.2008.02465.x
• Biolistic delivery of Ca2+ dyes into plant and algal cells
  
  Bothwell, J., Brownlee, C., Hetherington, A., Ng, C., Wheeler, G., & McAinsh, M. (2006). Biolistic delivery of Ca2+ dyes into plant and algal cells. Plant Journal, 46(2), 327-335. https://doi.org/10.1111/j.1365-313x.2006.02687.x
• The long past of systems biology
  
  Bothwell, J. (2006). The long past of systems biology. New Phytologist, 170(1), 6-10. https://doi.org/10.1111/j.1469-8137.2006.01676.x
• The evolution of Ca2+ signalling in photosynthetic eukaryotes
  
  Bothwell, J., & Ng, C. (2005). The evolution of Ca2+ signalling in photosynthetic eukaryotes. New Phytologist, 166(1), 21-38. https://doi.org/10.1111/j.1469-8137.2004.01312.x
• Reactive oxygen species produced by NADPH oxidase regulate plant cell growth
  
  Foreman, J., Demidchik, V., Bothwell, J., Mylona, P., Miedema, H., Torres, M., Linstead, P., Costa, S., Brownlee, C., Jones, J., Davies, J., & Dolan, L. (2003). Reactive oxygen species produced by NADPH oxidase regulate plant cell growth. Nature, 422(6930), 442-446. https://doi.org/10.1038/nature01485
• Abnormalities in brain biochemistry associated with lack of dystrophin: studies of the mdx mouse
  
  Rae, C., Griffin, J., Blair, D., Bothwell, J., Bubb, W., Maitland, A., & Head, S. (2002). Abnormalities in brain biochemistry associated with lack of dystrophin: studies of the mdx mouse. Neuromuscular Disorders, 12(2), 121-129. https://doi.org/10.1016/s0960-8966%2801%2900253-x
• Swelling-activated taurine and creatine effluxes from rat cortical astrocytes are pharmacologically distinct
  
  Bothwell, J., Styles, P., & Bhakoo, K. (2002). Swelling-activated taurine and creatine effluxes from rat cortical astrocytes are pharmacologically distinct. Journal of Membrane Biology, 185(2), 157-164. https://doi.org/10.1007/s00232-001-0121-2
• Calcium uptake by plant cells - channels and pumps acting in concert
  
  Miedema, H., Bothwell, J., Brownlee, C., & Davies, J. (2001). Calcium uptake by plant cells - channels and pumps acting in concert. Trends in Plant Science, 6(11), 514-519. https://doi.org/10.1016/s1360-1385%2801%2902124-0
• Hypo-osmotic swelling-activated release of organic osmolytes in brain slices: implications for brain oedema in vivo
  
  Bothwell, J., Rae, C., Dixon, R., Styles, P., & Bhakoo, K. (2001). Hypo-osmotic swelling-activated release of organic osmolytes in brain slices: implications for brain oedema in vivo. Journal of Neurochemistry, 77(6), 1632-1640. https://doi.org/10.1046/j.1471-4159.2001.00403.x
• Chloride channel antagonists perturb growth and morphology of Neurospora crassa
  
  Hanke, G., Northrop, F., Devine, G., Bothwell, J., & Davies, J. (2001). Chloride channel antagonists perturb growth and morphology of Neurospora crassa. FEMS Microbiology Letters, 201(2), 243-247. https://doi.org/10.1111/j.1574-6968.2001.tb10763.x