Skip to main content
Overview

Dr Karrera Djoko

Assistant Professor

PhD (Chemistry)


Affiliations
AffiliationRoom numberTelephone
Assistant Professor in the Department of Biosciences204a+44 (0) 191 33 40809

Biography

Research Program

Trace nutrient metal ions (iron, manganese, zinc, copper) are essential for the function of nearly half of all proteins but they are toxic to cells if present in excess or if inserted into the wrong sites. The battle to control metal availability is now recognised as a key component of host-pathogen interactions in so-called “Nutritional Immunity” and there is growing interest in developing agents that manipulate nutrient metal level and location as new antimicrobial therapeutics.

Key questions that drive our research program are:

1. How does host-imposed, metal-linked nutritional immunity impact bacterial physiology?

2. How do bacteria adapt to the effects of nutritional immunity?

3. When/where in the host do bacterial pathogens encounter metal ions?

4. Can we learn from nature and manipulate metal levels and locations as new antibacterial approaches?

Research interests

  • Metals in microbiology
  • Infectious diseases
  • Microbial physiology
  • Antimicrobial resistance
  • Antimicrobial development

Publications

Chapter in book

  • Turner, Andrew G., Ong, Cheryl-lynn Y., Walker, Mark J., Djoko, Karrera Y. & McEwan, Alastair G. (2017). Transition Metal Homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae. In Microbiology of Metal Ions. 70: 123-191.
  • Djoko, Karrera Y., Achard, Maud E.S. & McEwan, Alastair G. (2013). Copper in Immune Cells. In Encyclopedia of Inorganic and Bioinorganic Chemistry. 1-11.
  • McEwan, Alastair G., Djoko, Karrera Y., Chen, Nathan H., Couñago, Rafael L.M., Kidd, Stephen P., Potter, Adam J. & Jennings, Michael P. (2011). Novel Bacterial MerR-Like Regulators. In 58: 1-22.

Journal Article

Supervision students