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Associate Professor in the Department of Physics257+44 (0) 191 33 43598
Associate Professor in the Centre for Materials Physics257+44 (0) 191 33 43598
Member of the Biophysical Sciences Institute  
Associate Fellow in the Institute of Advanced Study  


I finished my undergraduate studies in Biophysics at the University of Sofia, Bulgaria. Shortly after, I went to Germany on a DAAD fellowship to do my PhD with Prof. J. Gimsa at the University of Rostock, where I graduated in 2006. During that time I studied theoretically the interaction of high frequency electromagnetic fields with cellular media, and in particular with lipid membranes. As a postdoc in the group of Dr. R. Dimova at the Max Planck Institute of Colloids and Interfaces (Germany) I switched to an experimental project on the electro-manipulation of lipid vesicles. In 2009, I moved to Princeton University to the Complex Fluid Group of Prof. Howard A. Stone, where I laid the foundation of my current research on the biophysics of biological membranes. Since October 2013 I am working as a lecturer in the departments of Physics and Chemistry at Durham University.

Research Interests
  • Biophysics
  • Biological membranes
  • Functional interfaces
  • Living materials

This objectives of the group are to understand the functional principles of biological membranes and capture them in artificially designed smart interfaces. We use engineering approaches and optical tools for quantitative measurements. We are part of the Biophysical Sciences Institute and the Durham Center for Soft Matter.

Currently our efforts are focused on elucidating the mechano-sensitive architecture and composition of the cell interface.

Protrusions expelled from compressed lipid bilayers. Shape is controlled by the applied strain and volume.

Cell interface- the crosstalk between structures

The cell interface is a multilayered ensemble, with the plasma membrane in the middle, the contractile actin cortex on the inner side, and an extracellular matrix or a cell wall, on the outer side. In this project we study how the coupling between these structurally and mechanically different layers shape the surface functionality of cells. For example, we were recently able to demonstrate that a lipid membrane coupled to an elastic substrate expels or absorbs reversibly lipid protrusions in response to changes in the substrate area, providing us with mechanical insights on how cells regulate their surface area (see Staykova et al., PRL13 and PNAS11- see picture on the right). Our goal is to build a realistic model of the cell interface, which explains the wrinkling, buckling, budding, tubulation and other vital forms of membrane deformation.

Molecular principles of membrane mechano-transductuion

It becomes apparent that the surface tension of biological membranes is a key regulator of numerous physiological processes in cells, like membrane traffic, cell motility, surface area regulation, etc. Tension arises from physical stresses both internal (from the cytoskeleton) and external acting on the membrane, and also from biochemically induced stresses from the binding of proteins or the insertion of small molecules into the membranes.

To understand the mechano-sensitivity of biological membranes we engineer devices that would allow us to apply well-defined mechanical stresses to model membranes of particular composition. Our goal is to relate the large-scale membrane deformations to changes on the molecular level, i.e. lipid packing, polysaccharide conformation, molecular adhesion and insertion.

Research groups


Chapter in book

Journal Article

Supervision students