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Overview

Dr Vincent Croset

Assistant Professor


Affiliations
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Assistant Professor in the Department of Biosciences  
Fellow of Wolfson Research Institute for Health and Wellbeing  

Biography

I obtained my PhD from the University of Lausanne (Switzerland), working on the evolution and function of a then novel family of chemosensory receptors, in the lab of Richard Benton. There, I traced the evolution of these receptors across the genomes of dozens of invertebrates, and found a function for one of them in tasting amino-acids. After graduating in 2013, I moved to the Centre for Neural Circuits and Behaviour at the University of Oxford to work with Scott Waddell on transcriptomic variability in the Drosophila brain. There, I generated the first atlas of single-cell transcriptomes from the fly brain, which I used to identify new genes that define cell types, and resolve transmitter co-expression and receptor assembly. I also used single-cell transcriptomics to address state-dependent gene expression changes induced by thirst. 

Research

In our brain, modulation of gene expression influences the activity of particular neurons and circuits to regulate essential functions such as memory, sleep, feeding or social interactions. In turn, neuronal activity and plasticity also influence the expression of specific genes, to regulate neurotransmission, and maintain homeostasis. We use the simple brain of the fruit fly Drosophila melanogaster as a model to understand the interplay between neuronal activity and transcription. Using single-cell transcriptomics, behaviour and neuronal imaging, we are able to identify novel genes and pathways that sustain key neuronal functions, with an unprecedented level of detail. Description of these mechanisms could inform treatments against neurological conditions, such as addiction or neurodegenerative diseases. 

Research interests

  • Neurosciences
  • Transcriptomics
  • Memory
  • Dopamine
  • Drosophila
  • Behaviour
  • Psychostimulants

Research groups

  • Animal Cells and Systems

Publications

Journal Article

  • Allen, A.M., Neville, M.C., Birtles, S., Croset, V., Treiber, C.D., Waddell, S. & Goodwin, S.F. (2020). A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord. eLife 9: e54074.
  • Sánchez-Alcañiz, J.A., Silbering, A.F., Croset, V., Zappia, G., Sivasubramaniam, A.K., Abuin, L., Sahai, S.Y., Münch, D., Steck, K., Auer, T.O., Cruchet, S., Neagu-Maier, G.L., Sprecher, S.G., Ribeiro, C., Yapici, N. & Benton, R. (2020). Publisher Correction: An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing (Nature Communications, (2018), 9, 1, (4252), 10.1038/s41467-018-06453-1). Nature Communications 11(1).
  • Croset, V., Treiber, C.D. & Waddell, S. (2018). Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics. eLife 7: e34550.
  • Sánchez-Alcañiz, J.A., Silbering, A.F., Croset, V., Zappia, G., Sivasubramaniam, A.K., Abuin, L., Sahai, S.Y., Münch, D., Steck, K., Auer, T.O., Cruchet, S., Neagu-Maier, G.L., Sprecher, S.G., Ribeiro, C., Yapici, N. & Benton, R. (2018). An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing. Nature Communications 9(1): 4252.
  • Knecht, Z.A., Silbering, A.F., Cruz, J., Yang, L., Croset, V., Benton, R. & Garrity, P.A. (2017). Ionotropic receptor-dependent moist and dry cells control hygrosensation in Drosophila. eLife 6.
  • Gulia-Nuss, M., Nuss, A.B., Meyer, J.M., Sonenshine, D.E., Roe, R.M., Waterhouse, R.M., Sattelle, D.B., De La Fuente, J., Ribeiro, J.M., Megy, K., Thimmapuram, J., Miller, J.R., Walenz, B.P., Koren, S., Hostetler, J.B., Thiagarajan, M., Joardar, V.S., Hannick, L.I., Bidwell, S., Hammond, M.P., Young, S., Zeng, Q., Abrudan, J.L., Almeida, F.C., Ayllón, N., Bhide, K., Bissinger, B.W., Bonzon-Kulichenko, E., Buckingham, S.D., Caffrey, D.R., Caimano, M.J., Croset, V., Driscoll, T., Gilbert, D., Gillespie, J.J., Giraldo-Calderón, G.I., Grabowski, J.M., Jiang, D., Khalil, S.M.S., Kim, D., Kocan, K.M., Koči, J., Kuhn, R.J., Kurtti, T.J., Lees, K., Lang, E.G., Kennedy, R.C., Kwon, H., Perera, R., Qi, Y., Radolf, J.D., Sakamoto, J.M., Sánchez-Gracia, A., Severo, M.S., Silverman, N., Šimo, L., Tojo, M., Tornador, C., Van Zee, J.P., Vázquez, J., Vieira, F.G., Villar, M., Wespiser, A.R., Yang, Y., Zhu, J., Arensburger, P., Pietrantonio, P.V., Barker, S.C., Shao, R., Zdobnov, E.M., Hauser, F., Grimmelikhuijzen, C.J.P., Park, Y., Rozas, J., Benton, R., Pedra, J.H.F., Nelson, D.R., Unger, M.F., Tubio, J.M.C., Tu, Z., Robertson, H.M., Shumway, M., Sutton, G., Wortman, J.R., Lawson, D., Wikel, S.K., Nene, V.M., Fraser, C.M., Collins, F.H., Birren, B., Nelson, K.E., Caler, E. & Hill, C.A. (2016). Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nature Communications 7.
  • Croset, V., Schleyer, M., Arguello, J.R., Gerber, B. & Benton, R. (2016). A molecular and neuronal basis for amino acid sensing in the Drosophila larva. Scientific Reports 6.
  • Chen, C., Buhl, E., Xu, M., Croset, V., Rees, J.S., Lilley, K.S., Benton, R., Hodge, J.J.L. & Stanewsky, R. (2015). Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature. Nature 527(7579): 516-520.
  • Rytz, R., Croset, V. & Benton, R. (2013). Ionotropic Receptors (IRs): Chemosensory ionotropic glutamate receptors in Drosophila and beyond. Insect Biochemistry and Molecular Biology 43(9): 888-897.
  • Smith, C.R., Smith, C.D., Robertson, H.M., Helmkampf, M., Zimin, A., Yandell, M., Holt, C., Hu, H., Abouheif, E., Benton, R., Cash, E., Croset, V., Currie, C.R., Elhaik, E., Elsik, C.G., Favé, M.-J., Fernandes, V., Gibson, J.D., Graur, D., Gronenberg, W., Grubbs, K.J., Hagen, D.E., Viniegra, A.S.I., Johnson, B.R., Johnson, R.M., Khila, A., Kim, J.W., Mathis, K.A., Munoz-Torres, M.C., Murphy, M.C., Mustard, J.A., Nakamura, R., Niehuis, O., Nigam, S., Overson, R.P., Placek, J.E., Rajakumar, R., Reese, J.T., Suen, G., Tao, S., Torres, C.W., Tsutsui, N.D., Viljakainen, L., Wolschind, F. & Gadau, J. (2011). Draft genome of the red harvester ant Pogonomyrmex barbatus. Proceedings of the National Academy of Sciences of the United States of America 108(14): 5667-5672.
  • Smith, C.D., Zimin, A., Holt, C., Abouheif, E., Benton, R., Cash, E., Croset, V., Currie, C.R., Elhaik, E., Elsik, C.G., Fave, M.-J., Fernandes, V., Gadau, J., Gibson, J.D., Graur, D., Grubbs, K.J., Hagen, D.E., Helmkampf, M., Holley, J.-A., Hu, H., Viniegra, A.S.I., Johnson, B.R., Johnson, R.M., Khila, A., Kim, J.W., Laird, J., Mathis, K.A., Moeller, J.A., Muñoz-Torres, M.C., Murphy, M.C., Nakamura, R., Nigam, S., Overson, R.P., Placek, J.E., Rajakumar, R., Reese, J.T., Robertson, H.M., Smith, C.R., Suarez, A.V., Suen, G., Suhr, E.L., Tao, S., Torres, C.W., Van Wilgenburg, E., Viljakainen, L., Walden, K.K.O., Wild, A.L., Yandell, M., Yorke, J.A. & Tsutsui, N.D. (2011). Draft genome of the globally widespread and invasive Argentine ant (Linepithema humile). Proceedings of the National Academy of Sciences of the United States of America 108(14): 5673-5678.
  • Croset, V., Rytz, R., Cummins, S.F., Budd, A., Brawand, D., Kaessmann, H., Gibson, T.J. & Benton, R. (2010). Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. PLoS Genetics 6(8).
  • Gutjahr, C., Banba, M., Croset, V., An, K., Miyao, A., An, G., Hirochika, H., Imaizumi-Anraku, H. & Paszkowski, U. (2008). Arbuscular Mycorrhiza-Specific Signaling in Rice Transcends the Common Symbiosis Signaling Pathway. Plant Cell 20(11): 2989-3005.

Supervision students