CHEM4211: BIOACTIVE CHEMISTRY 4

• Bioactive Chemistry 3 (CHEM3211), Advanced Organic Chemistry (CHEM3117) AND Biological Chemistry (CHEM2051).

• Bioactive Chemistry Research Project (CHEM4272), Biochemistry Research Project (BIOL4022),

• Core Chemistry 4 (CHEM4311) AND Advanced Research Concepts in Chemistry (CHEM4481).

• To build on material taught at level three and provide students with an advanced overview of more specialised areas of chemistry at the interface with biology.

• I - Medicinal Chemistry I - Drug design, discovery and development
• J - Advanced Polymer Synthesis
• K - Carbenes in Organocatalysis
• M - Enantioselective Catalysis
• N - Organofluorine Chemistry
• O - Introduction to Agrochemistry
• U - Medicinal Chemistry II - From hit to pill
• [*Each student will follow six lecture courses.].

Subject-specific Knowledge:

• After attending the relevant lecture courses, students should be able to:
• I1 - Classify drugs according to their site and mode of action and critically discuss the relationships between structure and activity;
• I2 - Describe methods by which drugs may be discovered and optimised;
• J1 - Describe and distinguish between the major synthetic routes to polymer molecules
• J2 - Understand the relative merits and limitations of each synthetic route and suggest suitable strategies for the synthesis of key polymer classes
• K1 - Identify different classes of carbene organocatalysts and synthetic routes to these catalysts;
• K2 - Discuss typical mechanisms of reactions enabled by carbenes including acyl anion, Lewis base and azolium enolate catalysis;
• M1 - understand and exemplify the key strategies used in the construction of complex chemical scaffolds;
• M2 - devise retrosynthetic strategies and provide forward synthetic routes to the construction of complex targets;
• N1 - Describe several methods for the introduction of fluorine atoms into organic systems
• N2 - Discuss reactivity and mechanisms of fluoroalkenes, aromatics, heterocyclics and a mirror-image chemistry of related hydrocarbon systems
• O1 - To Appreciate the societal importance of crop protection agents and other agrochemicals
• O2 - To Distinguish between intrinsic and biological effects of agrochemical inputs
• O3 - To Understand how an agrochemical can interact with its molecular target
• O4 - To be able to relate molecular structure to physicochemical parameters and downstream impact on compound efficacy
• O5 - To understand the steps of early stage agrochemical discovery - lead discovery and lead optimisation
• U1 - Understand the process of developing a successful "hit" from drug discovery into a final product;
• U2 - Understand the importance of solid-state forms and their characterisation for drug pharmacokinetics and patenting;

Subject-specific Skills:

Key Skills:

• Facts and new concepts are introduced in the lecture courses.
• Students' knowledge and understanding is tested by examination.
• Undergraduates are aided in the learning process by workshops where they attempt sample problems about the lecture courses.

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