Skip to main content
Overview
Affiliations
AffiliationTelephone
Head Of Department in the Department of Biosciences+44 (0) 191 33 43985
Head of Department in the Department of Biosciences+44 (0) 191 33 41330
Fellow of the Wolfson Research Institute for Health and Wellbeing+44 (0) 191 33 43985

Biography

We are based within the Department of Chemistry and work closely with physicists, chemists, and mathematicians.

Carbon dioxide sensing.

CO2 is essential for life. It is at the beginning of every life process as a fundamental substrate of photosynthesis or chemosynthesis and is at the end of every life process as the product of aerobic respiration and post-mortem decay. As such, it is not a surprise that this gas regulates such diverse processes as cellular chemical reactions, transport, maintenance of the cellular environment, behaviour and immunity. CO2 is a strategically importnt research target with relevance to crop responses to environmental change, insect vector borne disease and public health. However, we know very little of the direct interactions of CO2 with the cell, despite the importance of the gas to biology.

Our current work is directed toward understanding how CO2 impacts on cell function in diverse model systems, particularly through the carbamate post-translational modification on the lysine epsilon-amino group. 

 

 

Research interests

  • Bicarbonate
  • Biochemistry
  • Carbon dioxide
  • Cell biology
  • Hypercapnia
  • Hypocapnia
  • Inorganic carbon
  • Molecular biology
  • Signal transduction

Esteem Indicators

  • 2023: Fellow of the Royal Society of Chemistry:
  • 2022: RCUK Committee Membership: Chair Panel D
  • 2021: Fellow of the Royal Society of Biology:
  • 2020: Institute of Physics: Rosalind Franklin Silver Medal (co-awardee)
  • 2003: Fellowship: Leverhulme Trust Research Fellow 2003-2005

Publications

Authored book

Chapter in book

Journal Article

Supervision students