Staff profile
Overview
Dr Martin Schroeder
Associate Professor
Affiliation | Telephone |
---|---|
Associate Professor in the Department of Biosciences | +44 (0) 191 33 41316 |
Biography
Ph.D. Technical University of Darmstadt, Darmstadt, Germany, 1996.
Postdoctoral Fellow, Howard Hughes Medical Institute and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA, 1997 - 2004.
Research interests
- Molecular Biology
- Unfolded Protein Response
- Yeast Genetics
Publications
Authored book
- Schröder, M. (2010). Molecular chaperones of the endoplasmic reticulum. Nova Science Publishers
- Schröder, M. (1997). Identifikation limitierter Schritte der Antithrombin III Produktion in genamplifizierten CHO-Zellen. Shaker
Chapter in book
- Schröder, M. (2009). Molecular chaperones of the endoplasmic reticulum. In P. Durante, & L. Colucci (Eds.), Handbook of Molecular Chaperones: Roles, Structures and Mechanisms (1-78). Nova Science Publishers
- Schröder, M. (2008). Unfolded protein response. In J. Weil, D. Blumel, S. Malmoli, & J. Netting (Eds.), Yearbook of Science and Technology (356-360). McGraw-Hill
- Frech, M., Mikosch, T., Schröder, M., & Stassen, M. (2007). Allgemeine Methoden. In M. Jansohn (Ed.), Gentechnische Methoden: eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor (1-35). (4th ed.). Elsevier
- Strudwick, N., & Schröder, M. (2007). The unfolded protein response. In M. Al-Rubeai, & M. Fussenegger (Eds.), Cell Engineering Vol 5: Systems Biology (69-157). Springer Netherlands
- Schröder, M. (2007). Isolierung von RNA. In M. Jansohn (Ed.), Gentechnische Methoden (131-154). Elsevier
- Schröder, M. (2007). The cellular response to protein unfolding stress. In G. Robson, P. van West, & G. Gadd (Eds.), BMS Symposium Series, Exploitation of Fungi (117-139). Cambridge University Press
- Frech, M., Mikosch, T., Schröder, M., & Stassen, M. (2002). Allgemeine Methoden. In G. Schrimpf, & A. Aigner (Eds.), Gentechnische Methoden: eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor (1-37). (3rd ed.). Spektrum Akademischer Verlag
- Schröder, M. (2002). Isolierung von RNA. In G. Schrimpf (Ed.), Gentechnische Methoden (129-145). (3). Spektrum Academischer Verlag
- Schröder, M. (1999). Isolierung von RNA. In H. Gassen, & G. Schrimpf (Eds.), Genrechnische Methoden (225-242). (2). Spektrum Akademischer Verlag
- Schrimpf, G., Schröder, M., Weitnauer, E., & Friedl, P. (1995). Metabolism of confluent vascular endothelial cell cultures. In E. Beuvery, J. Griffiths, & W. Zeijlemaker (Eds.), Animal Cell Technology: Developments towards the 21st century (1127-1131). Kluwer Academic Publishers
Journal Article
- Read, A., & Schröder, M. (2021). The Unfolded Protein Response: An Overview. Biology, 10(5), Article 384. https://doi.org/10.3390/biology10050384
- Brown, M., Dainty, S., Strudwick, N., Mihai, A. D., Watson, J. N., Dendooven, R., …Schröder, M. (2020). Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesised insulin receptors to the cell surface. Molecular Biology of the Cell, 31(23), 2495-2629. https://doi.org/10.1091/mbc.e18-01-0013
- Armstrong, M., Sestak, S., Ali, A., Sagini, H., Brown, M., Baty, K., …Schröder, M. (2017). Bypass of activation loop phosphorylation by aspartate 836 in activation of the endoribonuclease activity of Ire1. Molecular and Cellular Biology, 37(16), e00655-16. https://doi.org/10.1128/mcb.00655-16
- Brown, M., Strudwick, N., Suwara, M., Sutcliffe, L., Mihai, A., Ali, A., …Schröder, M. (2016). An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response. Journal of Cell Science, 129(12), 2317-2328. https://doi.org/10.1242/jcs.179127
- Mihai, A., & Schröder, M. (2015). Glucose starvation and hypoxia, but not the saturated fatty acid palmitic acid or cholesterol, activate the unfolded protein response in 3T3-F442A and 3T3-L1 adipocytes. Adipocyte, 4(3), 188-202. https://doi.org/10.4161/21623945.2014.989728
- Skipsey, M., Hack, G., Hooper, T., Shankey, M., Conway, L., Schröder, M., & Hodgson, D. (2013). 5’-Deoxy-5’-hydrazinylguanosine as an initiator of T7 RNA polymerase-catalyzed transcriptions for the preparation of labeling-ready RNAs. Nucleosides, Nucleotides and Nucleic Acids, 32(12), 670-681. https://doi.org/10.1080/15257770.2013.851393
- Hodgson, D., & Schröder, M. (2011). Chemical approaches twoards unraveling kinase-mediated signaling pathways. Chemical Society Reviews, 40(3), 1211-1223
- Cox, D., Srudwick, N., Ali, A., Paton, A., Paton, J., & Schröder, M. (2011). Measuring signaling by the unfolded protein response. Methods in enzymology, 491, 261-292. https://doi.org/10.1016/b978-0-12-385928-0.00015-8
- Strudwick, N., Brown, M., Parmar, V., & Schröder, M. (2010). Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on Nonfermentable Carbon Sources. Molecular and Cellular Biology, 30(23), 5514-5530. https://doi.org/10.1128/mcb.00390-10
- Schröder, M., & Sutcliffe, L. (2010). Consequences of stress in the secretory pathway: the ER stress response and its role in the metabolic syndrome. Methods in molecular biology (Clifton, N.J. Online), 648, 43-62. https://doi.org/10.1007/978-1-60761-756-3_3
- Schröder, M. (2008). Endoplasmic reticulum stress responses. Cellular and Molecular Life Sciences, 65(6), 862-894. https://doi.org/10.1007/s00018-007-7383-5
- Khan, S., & Schröder, M. (2008). Engineering of chaperone systems and of the unfolded protein response. Cytotechnology, 57(3), 207-231. https://doi.org/10.1007/s10616-008-9157-9
- Schröder, M. (2008). Engineering eukaryotic protein factories. Biotechnology Letters, 30(2), 187-196. https://doi.org/10.1007/s10529-007-9524-1
- Schröder, M., & Kohno, K. (2007). Recent advances in understanding the unfolded protein response. Antioxidants and Redox Signaling, 9(12), 2241-2244. https://doi.org/10.1089/ars.2007.1877
- Schröder, M., & Kaufman, R. (2007). Ire1. The AFCS-nature molecule pages, https://doi.org/10.1038/mp.a003134.01
- Schröder, M. (2006). The unfolded protein response. Molecular Biotechnology, 34(2), 279-290
- Schröder, M., & Kaufman, R. (2006). Divergent roles for IRE1α and PERK in the unfolded protein response. Current Molecular Medicine, 6(1), 5-36
- Back, S., Schröder, M., Lee, K., Zhang, K., & Kaufman, R. (2005). ER stress signalling by regulated splicing: IRE1/HAC1/XBP1. Methods, 35(4), 395-416. https://doi.org/10.1016/j.ymeth.2005.03.001
- Schröder, M., & Kaufman, R. (2005). ER stress and the unfolded protein response. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 569(1-2), 29-63. https://doi.org/10.1016/j.mrfmmm.2004.06.056
- Schröder, M., & Kaufman, R. (2005). The mammalian unfolded protein response. Annual Review of Biochemistry, 74, 739-789
- Schröder, M., Clark, R., Liu, C., & Kaufman, R. (2004). The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase. The EMBO Journal, 23(11), 2281-2292. https://doi.org/10.1038/sj.emboj.7600233
- Schröder, M., Matischak, K., & Friedl, P. (2004). Serum- and protein-free media formulations for the Chinese hamster ovary cell line DUKXB11. Journal of Biotechnology, 108(3), 279-292. https://doi.org/10.1016/j.jbiotec.2003.12.005
- Wiederkehr, C., Basavaraj, R., Sarrauste de Menthiere, C., Hermida, L., Koch, R., Schlecht, U., …Primig, M. (2004). GermOnline, a cross-species knowledgebase on germ cell differentiation. Nucleic Acids Research, 32(Database issue), D560-D567. https://doi.org/10.1093/nar/gkh055
- Schröder, M., Clark, R., & Kaufman, R. (2003). IRE1- and HAC1-independent transcriptional regulation in the unfolded protein response of yeast. Molecular Microbiology, 49(3), 591-606. https://doi.org/10.1046/j.1365-2958.2003.03585.x
- Kaufman, R., Scheuner, D., Schröder, M., Shen, X., Lee, K., Liu, C., & Arnold, S. (2002). The unfolded protein response in nutrient sensing and differentiation. Nature Reviews Molecular Cell Biology, 3(6), 411-421. https://doi.org/10.1038/nrm829
- Schröder, M., Schäfer, R., & Friedl, P. (2002). Induction of protein aggregation in an early secretory compartment by elevation of expression level. Biotechnology and Bioengineering, 78(2), 131-140. https://doi.org/10.1002/bit.10206
- Schröder, M., Chang, J., & Kaufman, R. (2000). The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast. Genes & Development, 14(23), 2962-2975
- Liu, C., Schröder, M., & Kaufman, R. (2000). Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. Journal of Biological Chemistry, 275(32), 24881-24885
- Schröder, M., Körner, C., & Friedl, P. (1999). Quantitative analysis of transcription and translation in gene amplified Chinese hamster ovary cells on the basis of a kinetic model. Cytotechnology, 29(2), 93-102. https://doi.org/10.1023/a%3A1008077603328
- Schröder, M., & Friedl, P. (1997). Enzymatic determination of D-glucose in cell culture media using glucose oxidase, horseradish peroxidase and 3,3 ',5,5 '- tetramethylbenzidine
- Schröder, M., & Friedl, P. (1997). A protein-free solution as replacement for serum in trypsinization protocols for anchorage-dependent cells. Methods in cell science, 19(2), 137-147. https://doi.org/10.1023/a%3A1009792705772
- Schröder, M., & Friedl, P. (1997). Overexpression of recombinant human antithrombin III in Chinese hamster ovary cells results in malformation and decreased secretion of the recombinant protein. Biotechnology and Bioengineering, 53(6), 547-559. https://doi.org/10.1002/%28sici%291097-0290%2819970320%2953%3A6%3C547%3A%3Aaid-bit2%3E3.0.co%3B2-m
- Schröder, M., Schäfer, R., & Friedl, P. (1997). Spectrophotometric determination of iodixanol in subcellular fractions of mammalian cells. Analytical Biochemistry, 244(1), 174-176. https://doi.org/10.1006/abio.1996.9861
- Schröder, M., Kaiser, D., Schäfer, R., & Friedl, P. (1996). Indirect sandwich ELISA for human antithrombin III employing the interaction between D-biotin and streptavidin
- Schrimpf, G., Schröder, M., Weitnauer, E., & Friedl, P. (1994). Metabolic rates of vascular endothelial cells in vitro. Cytotechnology, 16(1), 43-50. https://doi.org/10.1007/bf00761778
Supervision students
Caitlin Gould
Research Postgraduate (MSc)
Haiyang Yu
Research Postgraduate (PhD)
Islam Hayajneh
Research Postgraduate (PhD)
Wanqiu Wang
Research Postgraduate (PhD)