Staff profile
Overview

Affiliation | Room number | Telephone |
---|---|---|
Associate Professor in the Department of Biosciences | ||
Visiting Associate Professor in the Department of Chemistry | CG204A |
Research interests
- metalloproteins
- bioinorganic chemistry
- protein engineering
- biotechnology
- microbiology
- protein chemistry
- biotechnology
- bacteriology
- nickel
Research groups
Publications
Chapter in book
- (2012). Urease and the bacterial acid-stress response. In Stress Response in Pathogenic Bacteria. CABI. 167-181.
Journal Article
- Foster, Andrew W., Young, Tessa R., Chivers, Peter T. & Robinson, Nigel J. (2022). Protein metalation in biology. Current Opinion in Chemical Biology 66: 102095.
- Osman, Deenah, Martini, Maria Alessandra, Foster, Andrew W., Chen, Junjun, Scott, Andrew J. P., Morton, Richard J., Steed, Jonathan W., Lurie-Luke, Elena, Huggins, Thomas G., Lawrence, Andrew D., Deery, Evelyne, Warren, Martin J., Chivers, Peter T. & Robinson, Nigel J. (2019). Bacterial sensors define intracellular free energies for correct enzyme metalation. Nature Chemical Biology 15(3): 241-249.
- Huang, H-T., Bobst, C. E., Iwig, J. S., Chivers, P. T., Kaltashov, I. & Maroney, M. J. (2018). Co(II) and Ni(II) binding of the Escherichia coli transcriptional repressor RcnR orders its N-terminus, alters helix dynamics, and reduces DNA affinity. Journal of Biological Chemistry 293(1): 324-332.
- Carr, CE, Musiani, F, Huang, H-T, Chivers, PT, Ciurli, S & Maroney, MJ (2017). Glutamate Ligation in the Ni(II)- and Co(II)-Responsive Escherichia coli Transcriptional Regulator, RcnR. Inorganic Chemistry 56(11): 6459-6476.
- Moore, S., Sowa, S., Schuchardt, C., Deery, E., Lawrence, A., Ramos, J., Billig, S., Birkemeyer, C., Chivers, P., Howard, J., Rigby, S., Layer, G. & Warren, M. (2017). Elucidation of the biosynthesis of the methane catalyst coenzyme F430. Nature 543(7643): 78-82.
- Foster, A.W., Pernil, R., Patterson, C.J., Scott, A.J.P., Pålsson, L.-O., Pal, R., Cummins, I., Chivers, P.T., Pohl, E. & Robinson, N.J. (2017). A tight tunable range for Ni(II) sensing and buffering in cells. Nature Chemical Biology 13(4): 409-414.
- Denby, K. J., Iwig, J., Bisson, C., Westwood, J., Rolfe, M. D., Sedelnikova, S. E., Higgins, K., Maroney, M. J., Baker, P. J., Chivers, P. T. & Green, J. (2016). The mechanism of a formaldehyde-sensing transcriptional regulator. Scientific Reports 6: 38879.
- Chivers, P.T. (2015). Nickel recognition by bacterial importer proteins. Metallomics 7(4): 590-595.
- Higgins, K. A., Hu, H. Q., Chivers, P. T. & Maroney, M. J (2013). The Effects of Select Histidine to Cysteine Mutations on Transcriptional Regulation by E. coli RcnR. Biochemistry 52(1): 84-97.
- Higgins, K. A., Chivers, P. T. & Maroney, M. J. (2012). Role of the N-terminus in determining metal-specific responses in the E. coli Ni- and Co-responsive metalloregulator, RcnR. Journal of the American Chemical Society 134(16): 7081-7093
- Chivers, P. T., Benanti, E. L., Heil-Chapdelaine, V., Iwig, J. S. & Rowe, J. L (2012). Identification of Ni-(L-His)2 as a substrate for NikABCDE-dependent nickel uptake in Escherichia coli. Metallomics 4(10): 1043 -1050
- Benanti, E. L. & Chivers, P. T. (2011). Helicobacter pylori NikR Protein Exhibits Distinct Conformations When Bound to Different Promoters. The Journal of Biological Chemistry 286(18): 15728-15737.
- Choi, S.S., Chivers, P. T. & Berg, D. E. (2011). Point mutations in Helicobacter pylori's fur regulatory gene that alter resistance to metronidazole, a prodrug activated by chemical reduction. PLoS ONE 6(3): e18236.
- Benanti, E.L. & Chivers, P.T. (2010). Geobacter uraniireducens NikR displays a DNA binding mode distinct from other members of the NikR family. Journal of Bacteriology 192(17): 4327-4336.
- Iwig, J.S. & Chivers, P.T. (2010). Coordinating intracellular nickel – metal-site structure-function relationships and the NikR and RcnR repressors. Natural Product Reports 27(5): 658-667.
- Herbst, R. W., Perovic, I., O'Brien, K., Chivers, P. T., Pochapsky, S., Pochapsky, T. & Maroney, M. J (2010). The communication between the zinc and nickel sites in dimeric HypA: Metal recognition and pH sensing. Journal of the American Chemical Society 132(30): 10338.
- Benanti, E. L. & Chivers, P. T. (2009). An intact urease assembly pathway is required to compete with NikR for nickel ions in Helicobacter pylori. Journal of Bacteriology 191(7): 2405-2408
- Iwig, J. S. & Chivers, P. T. (2009). DNA Recognition and Wrapping by Escherichia coli RcnR. Journal of Molecular Biology 393(2): 514–526.
- Iwig, J. S., Leitch, S., Herbst, R. W., Maroney, M. J. & Chivers, P. T. (2008). Ni(II) and Co(II) sensing by Escherichia coli RcnR. Journal of the American Chemical Society 130(24): 7592–7606.
- Bradley, M.J., Chivers, P.T. & Baker, N.A. (2008). Molecular dynamics simulation of the Escherichia coli NikR protein: equilibrium conformational fluctuations reveal interdomain allosteric communication pathways. Journal of Molecular Biology 378(5): 1155-1173.
- Chivers, P. T. (2007). A Galvanizing Story – Protein Stability and Zinc Homeostasis. Journal of Bacteriology 189(8): 2953-2954.
- Leitch, S., Bradley, M. J., Rowe, J. L., Chivers, P. T. & Maroney, M. J (2007). Nickel-specific response in the transcriptional regulator, Escherichia coli NikR. Journal of the American Chemical Society 129(16): 5085-5095.
- Benanti, E.L. & Chivers, P. T. (2007). The N-terminal arm of the Helicobacter pylori Ni2+-dependent transcription factor NikR is required for specific DNA binding. Journal of Biological Chemistry 282(28): 20365.
- Kennedy, D. C., Herbst, R. W., Iwig, J. S., Chivers, P. T. & Maroney, M. J (2007). A Dynamic Zn Site in Helicobacter pylori HypA: A Potential Mechanism for Metal-Specific Protein Activity. Journal of the American Chemical Society 129(1): 16.
- Iwig, J. S., Rowe, J. L. & Chivers, P. T. (2006). Nickel homeostasis in Escherichia coli – the rcnR-rcnA efflux pathway and its linkage to NikR function. Molecular Microbiology 62(1): 252.
- Rowe, J.L., Starnes, G.L. & Chivers, P.T. (2005). Complex transcriptional control links NikABCDE-dependent nickel transport with hydrogenase expression in Escherichia coli. Journal of Bacteriology 187(18): 6317-6323.
Supervision students
Mrs Amnah Obidan
Research Postgraduate (PhD)
Mr. Jarred Roels
Research Postgraduate (PhD)
Mr John Bolton
Research Postgraduate (PhD)
Mr. John Richards
Research Postgraduate (MSc)
Miss Samantha Firth
Research Postgraduate (PhD)