Staff profile

• metalloproteins
• bioinorganic chemistry
• protein engineering
• biotechnology
• microbiology
• protein chemistry
• biotechnology
• bacteriology
• nickel

• Biomolecular Interactions

Chapter in book

• (2012). Urease and the bacterial acid-stress response. In Stress Response in Pathogenic Bacteria. CABI. 167-181.

Journal Article

• Foster, Andrew W., Young, Tessa R., Chivers, Peter T. & Robinson, Nigel J. (2022). Protein metalation in biology. Current Opinion in Chemical Biology 66: 102095.
• Osman, Deenah, Martini, Maria Alessandra, Foster, Andrew W., Chen, Junjun, Scott, Andrew J. P., Morton, Richard J., Steed, Jonathan W., Lurie-Luke, Elena, Huggins, Thomas G., Lawrence, Andrew D., Deery, Evelyne, Warren, Martin J., Chivers, Peter T. & Robinson, Nigel J. (2019). Bacterial sensors define intracellular free energies for correct enzyme metalation. Nature Chemical Biology 15(3): 241-249.
• Huang, H-T., Bobst, C. E., Iwig, J. S., Chivers, P. T., Kaltashov, I. & Maroney, M. J. (2018). Co(II) and Ni(II) binding of the Escherichia coli transcriptional repressor RcnR orders its N-terminus, alters helix dynamics, and reduces DNA affinity. Journal of Biological Chemistry 293(1): 324-332.
• Carr, CE, Musiani, F, Huang, H-T, Chivers, PT, Ciurli, S & Maroney, MJ (2017). Glutamate Ligation in the Ni(II)- and Co(II)-Responsive Escherichia coli Transcriptional Regulator, RcnR. Inorganic Chemistry 56(11): 6459-6476.
• Moore, S., Sowa, S., Schuchardt, C., Deery, E., Lawrence, A., Ramos, J., Billig, S., Birkemeyer, C., Chivers, P., Howard, J., Rigby, S., Layer, G. & Warren, M. (2017). Elucidation of the biosynthesis of the methane catalyst coenzyme F430. Nature 543(7643): 78-82.
• Foster, A.W., Pernil, R., Patterson, C.J., Scott, A.J.P., Pålsson, L.-O., Pal, R., Cummins, I., Chivers, P.T., Pohl, E. & Robinson, N.J. (2017). A tight tunable range for Ni(II) sensing and buffering in cells. Nature Chemical Biology 13(4): 409-414.
• Denby, K. J., Iwig, J., Bisson, C., Westwood, J., Rolfe, M. D., Sedelnikova, S. E., Higgins, K., Maroney, M. J., Baker, P. J., Chivers, P. T. & Green, J. (2016). The mechanism of a formaldehyde-sensing transcriptional regulator. Scientific Reports 6: 38879.
• Chivers, P.T. (2015). Nickel recognition by bacterial importer proteins. Metallomics 7(4): 590-595.
• Higgins, K. A., Hu, H. Q., Chivers, P. T. & Maroney, M. J (2013). The Effects of Select Histidine to Cysteine Mutations on Transcriptional Regulation by E. coli RcnR. Biochemistry 52(1): 84-97.
• Higgins, K. A., Chivers, P. T. & Maroney, M. J. (2012). Role of the N-terminus in determining metal-specific responses in the E. coli Ni- and Co-responsive metalloregulator, RcnR. Journal of the American Chemical Society 134(16): 7081-7093
• Chivers, P. T., Benanti, E. L., Heil-Chapdelaine, V., Iwig, J. S. & Rowe, J. L (2012). Identification of Ni-(L-His)2 as a substrate for NikABCDE-dependent nickel uptake in Escherichia coli. Metallomics 4(10): 1043 -1050
• Benanti, E. L. & Chivers, P. T. (2011). Helicobacter pylori NikR Protein Exhibits Distinct Conformations When Bound to Different Promoters. The Journal of Biological Chemistry 286(18): 15728-15737.
• Choi, S.S., Chivers, P. T. & Berg, D. E. (2011). Point mutations in Helicobacter pylori's fur regulatory gene that alter resistance to metronidazole, a prodrug activated by chemical reduction. PLoS ONE 6(3): e18236.
• Benanti, E.L. & Chivers, P.T. (2010). Geobacter uraniireducens NikR displays a DNA binding mode distinct from other members of the NikR family. Journal of Bacteriology 192(17): 4327-4336.
• Iwig, J.S. & Chivers, P.T. (2010). Coordinating intracellular nickel – metal-site structure-function relationships and the NikR and RcnR repressors. Natural Product Reports 27(5): 658-667.
• Herbst, R. W., Perovic, I., O'Brien, K., Chivers, P. T., Pochapsky, S., Pochapsky, T. & Maroney, M. J (2010). The communication between the zinc and nickel sites in dimeric HypA: Metal recognition and pH sensing. Journal of the American Chemical Society 132(30): 10338.
• Benanti, E. L. & Chivers, P. T. (2009). An intact urease assembly pathway is required to compete with NikR for nickel ions in Helicobacter pylori. Journal of Bacteriology 191(7): 2405-2408
• Iwig, J. S. & Chivers, P. T. (2009). DNA Recognition and Wrapping by Escherichia coli RcnR. Journal of Molecular Biology 393(2): 514–526.
• Iwig, J. S., Leitch, S., Herbst, R. W., Maroney, M. J. & Chivers, P. T. (2008). Ni(II) and Co(II) sensing by Escherichia coli RcnR. Journal of the American Chemical Society 130(24): 7592–7606.
• Bradley, M.J., Chivers, P.T. & Baker, N.A. (2008). Molecular dynamics simulation of the Escherichia coli NikR protein: equilibrium conformational fluctuations reveal interdomain allosteric communication pathways. Journal of Molecular Biology 378(5): 1155-1173.
• Chivers, P. T. (2007). A Galvanizing Story – Protein Stability and Zinc Homeostasis. Journal of Bacteriology 189(8): 2953-2954.
• Leitch, S., Bradley, M. J., Rowe, J. L., Chivers, P. T. & Maroney, M. J (2007). Nickel-specific response in the transcriptional regulator, Escherichia coli NikR. Journal of the American Chemical Society 129(16): 5085-5095.
• Benanti, E.L. & Chivers, P. T. (2007). The N-terminal arm of the Helicobacter pylori Ni2+-dependent transcription factor NikR is required for specific DNA binding. Journal of Biological Chemistry 282(28): 20365.
• Kennedy, D. C., Herbst, R. W., Iwig, J. S., Chivers, P. T. & Maroney, M. J (2007). A Dynamic Zn Site in Helicobacter pylori HypA: A Potential Mechanism for Metal-Specific Protein Activity. Journal of the American Chemical Society 129(1): 16.
• Iwig, J. S., Rowe, J. L. & Chivers, P. T. (2006). Nickel homeostasis in Escherichia coli – the rcnR-rcnA efflux pathway and its linkage to NikR function. Molecular Microbiology 62(1): 252.
• Rowe, J.L., Starnes, G.L. & Chivers, P.T. (2005). Complex transcriptional control links NikABCDE-dependent nickel transport with hydrogenase expression in Escherichia coli. Journal of Bacteriology 187(18): 6317-6323.