28 July 2023 - 28 July 2023
3:00PM - 5:00PM
Hybrid event - TLC129, Teaching and Learning Centre and Zoom
Free
Alzheimer’s disease is a complex neurological disorder and the most common form of dementia. Currently, there are no fully approved diagnosis and treatment for Alzheimer’s disease.
A brain scan
The production, accumulation, and aggregation of proteins in the human brain are considered major hallmarks of the disease. Reactive oxygen species (ROS) are significant sources of biomolecular and mitochondrial damage, leading to oxidative stress in neuronal cells. Oxidative stress, mitochondrial dysfunction, neuroinflammation, and microglia all contribute significantly to the pathogenesis of the disease. In this talk, I shall discuss the current understanding of disease mechanisms and present our multipronged strategies for developing molecular tools and methods for the differential diagnosis and treatment of Alzheimer’s disease.
Speaker Bio
T. Govindaraju is a full professor at Bioorganic Chemistry Laboratory, New Chemistry Unit and Chair, Education Technology Unit, JNCASR, Bengaluru, India. He received his MSc (2000) from Bangalore University and Ph.D. (2006) from the National Chemical Laboratory, Pune, India. He carried out postdoctoral research at the University of Wisconsin-Madison, USA (2005–2006) and Max Planck Institute of Molecular Physiology, Dortmund, Germany (2006–2008). His research interests are at the interface of chemistry, biology, and biomaterials science, include Alzheimer’s disease, peptide chemistry, molecular probes, diagnostic therapy (theranostics), molecular architectonics, and silk-inspired biomimetics and biomaterials. He has more than 155 publications, >35 patents, and four books to his credit. He has founded a startup company (VNIR Biotechnologies Pvt. Ltd. http://vnir.life) to translate many of the inventions from his laboratory. His group has discovered a novel drug candidate with immense potential to treat Alzheimer’s disease and is licensed to a biopharma for further development.
Prof. Govindaraju is the recipient of several awards and honors, Alexander von Humboldt Fellowship (2006) of AvH Foundation, Germany, profiled as “India’s Young Blood” by Chemical and Engineering News (C&EN), ACS, Innovative Young Biotechnologist Award (2010), INSA Medal for Young Scientist (2011), Sir C V Raman Young Scientist Award (2014), CRSI Bronze Medal (2016), MRSI medal (2017), IPS-Young Scientist Award (2017), SwarnaJyanti Fellowship (2015-16), CDRI Award 2019 for Excellence in Drug Research, Special Lecture Award of Pharmaceutical Society of Japan at Kyoto University, National Prize for Research in Peptides and Nucleic Acids (2020), Shanti Swarup Bhatnagar Prize (2021) in chemical science, SASTRA-CNR Rao Award 2022, Bhagyatara Award 2022 (Punjab University), Sun Pharma Science Foundation Research Award 2022, Fellow of Royal Society of Chemistry (FRSC), London, UK, Fellow of Indian Academy of Sciences (FASc), Bengaluru, and National Technology Award (Translational Research) 2023, Govt. of India.
Prof. Govindaraju is on the Editorial Advisory Board of the Journal of Peptide Science (European Peptide Society-Wiley Publications). He is the founding member of Indian National Young Academy of Science (INYAS). He is currently serving as the secretary of Chemical Research Society of India (CRSI) and Indian Peptide Society (IPS).
Zoom link for online attendance.
Meeting ID: 931 4091 5820 Passcode: 486122
References
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