Biophysics of fluid-cell interactions in ciliated tissues

Fluid flows play a major role in biological systems. Blood flow, swimming microorganisms, and transport of pathogens in the lungs are just a few examples.  

Fluid-cell interactions fully contribute to the embryonic development of organ form and function, and tissue remodeling in pathologies like atherosclerosis. These are active processes regulated by the conjoint ability of cells to both actuate fluid flows and sense their mechano-chemical environment. Yet, these mechanisms are still poorly understood.  

This project aims at dissecting ‘the biophysics of fluid-cell interactions in ciliated tissues’ in development and diseases. Cilia are organelles used by myriads of eukaryotic cells to stir and sense the surrounding fluids. These hair-like structures provide motility to microorganisms and clear our lungs from germs, but also drive fluid flow in areas from the reproductive system to the brain. The diversity in the biological function of these systems is reflected in their spatial organization. Yet, the relation between the many forms and functions of ciliated systems, as well as their establishment during embryonic development, has just started to be investigated, and will be the focus of this project. 

The findings of this project will also be relevant in areas such as viral transport, airways infections, new drug delivery strategies, and bio inspired medical devices. 

To understand the crosstalk between fluid and cells, you will combine concepts from biological fluid dynamics, cell and tissue mechanics, and developmental biology. Methods will include a combination of mathematical modelling, live imaging, and experimental manipulation of model organisms such as Xenopus and zebrafish.  

The ideal applicant will have a background in engineering/physics, or biosciences. Both skills in low Reynolds fluid mechanics and transport phenomena, or aquatic model animals and cell biology will be an advantage. Retraining will be provided as appropriate to allow the applicant to work across disciplines and researchers with diverse scientific backgrounds. 

If you are interested in applying, in the first instance contact the supervisor, Francesco Boselli (francesco.boselli@durham.ac.uk), with a CV and covering letter detailing your reasons for applying for the project.