12 November 2021 - 12 November 2021
2:00PM - 4:00PM
Dr Rivka Isaacson (King’s College London), 2021 Judith Howard Lecture, Friday 12 November (2-4 pm).
This year the Prize Lecture will be held in person (TLC040) as well as being online register here to receive Zoom details.
We are very pleased to welcome Dr Rivka Isaacson (King’s College London) to Durham for the 2021 Judith Howard Lecture, the BSI’s flagship event, named in honour of Professor Judith Howard CBE FRS.
As well as the Howard Lecture we will also have a short talk by Dr Matthew Kitching (Durham Chemistry) about his group’s development of the first ever method to selectively prepare chiral ammonium cation centre. A news item about this research can be found here.
Abstract: The crowded cell interior relies on many quality control mechanisms to ensure the correct protein machinery is present in the right places at the right times. I will present two projects currently underway in our lab that unite within this theme. We use a range of biophysics techniques, including NMR, X-ray crystallography, cryo-electron microscopy, SAXS, EPR, native mass-spectrometry and more, to study structure, function and interactions of proteins involved in these processes.
Metabolic Shutdown in Sporulation
When certain bacteria find themselves in unfavourable growth conditions such as nutrient deprivation, they make a carefully choreographed lifestyle switch to a hardy dormant form called a spore which will survive harsh conditions and revive when the time is ripe. One aspect of sporulation is metabolic shutdown of the developing spore and I will present some work we have been doing to understand this process in Bacillus subtilis.
Triage of Mislocalised Proteins
In mammalian cells, a co-chaperone called SGTA (small, glutamine-rich, tetratricopeptide repeat protein alpha) plays a critical role in sorting hydrophobic parts of proteins that have become aberrantly exposed to the aqueous cytoplasm. These are thought to meet with one of three fates: targeting to a membrane, refolding by chaperones or degradation by the ubiquitin proteasome pathway. SGTA also stabilises steroid hormone receptors before they are activated for nuclear entry by their hormone ligands. I will show our recent findings on understanding this complex tweezer-like protein using a combination of methods.
14:10 Dr Rivka Isaacson (King’s College London)
15:00 Questions from the floor and virtual audience
15:10 Dr Matt Kitching (Durham University, Chemistry)
15.30 Questions from the floor and virtual audience
15.40 Concluding remarks
15.45 ECR focus session – a chance for ECRs to ask research career focussed questions