Bioscience Embedded within Chemistry - Acting Group Coordinator (2023/24): Dr Gary Sharples
Biomolecular interactions, including contacts between biological macromolecules (protein/protein or protein/nucleic acids) and protein-ligand interactions are central to biochemistry. This grouping addresses fundamental questions concerning, for example, the recognition of DNA by bacterial proteins, the biophysical basis of allostery and the supply of metals to proteins. Multiple projects aim to identify targets for new antimicrobial (and antiviral) compounds and typically exploit a wide range of chemical, biochemical, and biophysical methods.
More than half of the members of the group are located in embedded biology laboratories within the Department of Chemistry and PIs have close interactions with the Bioactive Chemistry and Synthesis grouping in Chemistry.
Douglas O Escrivani, Rebecca L Charlton, Marjolly B Caruso, Gabriela A Burle-Caldas, Maria Paula G Borsodi, Russolina B Zingali, Natalia Arruda-Costa, Marcos V Palmeira-Mello, Jéssica B de Jesus, Alessandra M T Souza, Bárbara Abrahim-Vieira, Stefanie Freitag-Pohl, Ehmke Pohl, Paul W Denny, Bartira Rossi-Bergmann, Patrick G Steel (2021). Chalcones identify cTXNPx as a potential antileishmanial drug target.PLOS Negelcted Tropical Diseases.
Linthwaite, V.L. and Pawloski, W. and Pegg, H.B.and Townsend, P.D.and Thomas, M.J. and Brown, A.P. and Hodgson, D.R.W. and Lorimer, G.H. and Fushman, D. and Cann, M.J. (2021) Ubiquitin is a carbon dioxide-binding protein., Science advances., 7 . eabi5507.
Sharples, Gary J., Heddle, Jonathan G., Kozak, Maciej, Taube, Michał, Hughes, Timothy R, Pålsson, Lars-Olof, Bowers, Laura Y., Curtis, Fiona A., Plewka, Jacek, Świątek, Sylwia, Paterson, Joy R., Jolma, Arttu, Yang, Ally W.H., Gittens, William H., Trotter, Alexander J., Balakrishnan, Dhanasekaran & Chakraborti, Soumyananda (2020). A bacteriophage mimic of the bacterial nucleoid-associated protein Fis. Biochemical Journal477(7): 1345-1362